Bromhexin Nicomed, 0.8 mg/ml 150 ml

Mucolytic agent with expectorant action. It reduces the viscosity of bronchial secretion due to depolarization of acidic polysaccharides contained in it and stimulation of secretory cells of the bronchial mucosa that produce secretion containing neutral polysaccharides. It is believed that bromhexin promotes the formation of surfactant.

Pharmacokinetics

Bromhexine is rapidly absorbed from the GI tract and undergoes intensive metabolism during “first passage” through the liver. Bioavailability is about 20%. In healthy patients Cmax in plasma is determined after 1 hour.

Widely distributed in body tissues. About 85-90% is excreted with urine mainly in the form of metabolites. The metabolite of bromhexin is ambroxol.

The binding of bromhexine to plasma proteins is high. T1/2 in the terminal phase is about 12 hours.

Bromhexin penetrates through the HEB. In small amounts it penetrates through the placental barrier.

Only small amounts are excreted in the urine with a T1/2 of 6.5 h.

The clearance of bromhexine or its metabolites may be decreased in patients with severe hepatic and renal impairment.

Indications

Active ingredient

Composition

Active ingredient:

bromhexine hydrochloride – 0.8 mg.

Auxiliary substances:

levomenthol,

hydrochloric acid 2 mol/L,

methyl parahydroxybenzoate,

Ethanol 96%,

sorbitol,

Purified water.

How to take, the dosage

Ingestion.

Adults and children over 10 years of age: 10-20 ml 3 times a day.

Children from 6 to 10 years: 5-10 ml 3 times a day.

Children from 3 to 6 years: 2.505 ml 3 times a day.

For ease of dosing, use the supplied measuring cup. During treatment it is recommended to drink enough fluids to maintain the secretolytic action of bromhexin.

Interaction

Bromhexin is not prescribed at the same time as cough suppressants (including those containing codeine), because they may make it difficult to cough up sputum liquefied by Bromhexin.

Bromhexin promotes penetration of antibiotics (erythromycin, cephalexin, oxytetracycline, ampicillin, amoxicillin), sulfonamide drugs into the bronchial secretion.

The drug is incompatible with alkaline solutions.

Special Instructions

For diabetic patients: 5 ml of the solution contains 1.5 g of sorbitol, which corresponds to 0.12 bread units.

The drug contains alcohol in the concentration of 3%, which is 0.6 g per one dose of the drug for adults (20 ml), respectively, for children (2.5 ml) – 0.075 g.

Impact on the ability to drive and operate machinery

The administration of the recommended therapeutic doses (20 ml) has no effect on the speed of psychomotor reactions of the patient.

Significant exceeding of the recommended doses of a product containing 3% alcohol may affect the speed of psychomotor reactions and be dangerous when driving or operating machinery.

Contraindications

The presence of alcohol in the drug (96%) may have adverse effects on children, pregnant women, people with brain diseases, epilepsy, with craniocerebral trauma, alcoholism.

If you have any of the diseases or conditions listed in this section, the patient should consult a physician before use.

Side effects

Dyspepsia, including: nausea, vomiting; exacerbation of gastric and duodenal ulcer disease; allergic reactions; dizziness; headache; increased activity of “liver” transaminases in blood serum.

Overdose

Symptoms: nausea, vomiting, diarrhea and other gastrointestinal disorders.

Treatment: there is no specific antidote. In case of overdose it is necessary to induce vomiting and then the patient should be given fluids (milk or water). Gastric lavage is recommended within 1 – 2 hours after taking the drug.

Similarities