Blemaren, 80 pcs.

How to take, the dosage

The daily dose is 2 to 6 tablets.

The daily dose is evenly divided into 3 equal parts and taken after meals during the day. The effectiveness of the drug is monitored by determining the pH of fresh urine 3 times a day before the next administration of the drug with the indicator paper enclosed in each packet.

The indicator zone of the test strip should be dipped into the urine for 5-10 seconds, then you should take it out and after 2 minutes compare the obtained color of the test strip with the color scale, printed on the set of indicator strips. The obtained pH value should be recorded in the control calendar, which is enclosed in the pack.

On the basis of the received data the doctor chooses the individual dosage for the purpose of effective therapy.
The dose is considered to be chosen correctly in the case if the pH during the day is within the recommended limits for each reading.

For dissolution of uric acid stones, urine pH should be between 7.0 and 7.2. To dissolve urate-oxalate mixed stones and prevent the formation of calcium-oxalate stones, urine pH should be maintained at 6.8 – 7.4.

To alkalize urine in patients with cystine stones, urine pH should be in the 7.5 – 8.5 range. For the treatment of porphyria, urine pH should be between 7.2 and 7.5. For treatment with cytostatics, urine pH should be at least 7.0. If the urine pH value is lower than this, the dose should be increased, if it is higher – reduced. The duration of treatment should be at least 4-6 months.

In the presence of cystine stones and porphyria treatment, a special indicator paper should be used to determine the pH in the range of 7.2 – 9.7 (not included in the kit) to monitor the effectiveness.

Interaction

Simultaneous administration of drugs containing citrates and aluminum may lead to increased aluminum absorption. The interval between intakes of such drugs should be at least 2 hours.

The effect of cardiac glycosides may be impaired if simultaneously administered with the drug Blemaren® due to the presence of potassium in the drug.

Some drugs that lower blood pressure (aldosterone antagonists, potassium-saving diuretics, angiotensin-converting enzyme blockers, sartans) and anti-inflammatory non-steroidal drugs and analgesics may decrease potassium excretion.

Special Instructions

The average daily dose (4 effervescent tablets) contains about 1.5 mg of potassium and 0.9 g of sodium (to be considered in patients with limited intake of table salt).

It can be used in chronic renal failure that is not accompanied by retention of potassium ions.

Patients with diabetes can be prescribed.

In the dissolution of uric acid stones, excessive alkalinization of the urine should not be allowed for several days, because if the pH is increased above 7.8, phosphate precipitate may appear on the surface of the uric acid crystals, which may prevent further dissolution.

At the time of treatment, the intake of foods rich in proteins and purine bases should be limited, and sufficient fluid intake (at least 1.5-2 liters) should be provided.

Synopsis

Round, white, beveled, flat cylindrical tablets with a faint lemon odor.

Contraindications

• Hypersensitivity;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
• .acute and chronic renal failure;
• metabolic alkalosis;
• urinary tract infections caused by urea-degrading microorganisms;
• hereditary sporadic adynamism;
• the need for a strict salt-free diet (e.g., in severe forms of arterial hypertension)
• children under 12 years of age (because there is insufficient clinical experience regarding this age group).

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Side effects

According to the World Health Organization (WHO), adverse effects are classified according to their frequency of occurrence as follows: Very often (> 1/10), often (> 1/100, < 1/10), infrequently (> 1/1000, < 1/100), rarely (> 1/10000, < 1/1000) and very rarely (< 1/10000); frequency is unknown (frequency of the events cannot be determined based on available data).

In case of individual intolerance to the drug components allergic reactions are possible.

Gastrointestinal tract: often – abdominal pain, nausea, vomiting, diarrhea.

Metabolism and nutrition: frequency is unknown – edema (sodium retention), metabolic alkalosis.

Overdose

In normal renal function, undesirable effects of the drug on changes in physiological metabolic parameters have not been noted, neither at the usual recommended dose nor at a higher dose, because excretion of excessive alkalis by the kidneys is a natural mechanism for regulating the acid-base balance in the body.

The upper limit of the urine pH range specified above should not be exceeded for several days, because there is an increased risk of crystallization of phosphate due to elevated pH (pH > 7.8).

Possible overdose can be corrected by reducing the dose of the drug. If necessary, measures can be taken to treat metabolic alkalosis.

Pregnancy use

There are no confirmed data on the undesirable effect of the drug Blemarin® during pregnancy and breastfeeding. Administration of the drug is possible after consultation with a physician.