Biosulin N, 100 me/ml suspension 3 ml cartridge 5 pcs

Biosulin H is a medium-acting insulin preparation. It is a human insulin obtained using recombinant DNA technology.

It interacts with specific receptor of outer cytoplasmic cell membrane and forms insulin-receptor complex, stimulating intracellular processes, including synthesis of several key enzymes (including hexokinase, pyruvate kinase, glycogen synthetase).

The decrease of glucose in blood is caused by the increase of its intracellular transport, increased absorption and assimilation by tissues, stimulation of lipogenesis and glycogenogenesis and decrease of glucose production by liver.

The duration of action of Biosulin H is mainly due to the rate of absorption, which depends on several factors (e.g., dose, route and site of administration), so that the action profile of insulin is subject to significant variations both between and within the same patient.

Indications

Type 2 diabetes, Type 1 diabetes

– Type 1 diabetes (insulin-dependent);
– Type 2 diabetes (insulin-independent): stage of resistance to oral hypoglycemic agents, partial resistance to these drugs (when combined therapy), intercurrent diseases.

Composition

1 ml of suspension for subcutaneous administration contains:

active ingredient:

human isophane insulin 100 units

How to take, the dosage

The dose of Biosulin N is determined by the doctor individually, in each case based on the level of glucose in the blood.
The drug is intended for p / n administration.

The average daily dose varies from 0.5 to 1 IU/kg of body weight (depending on the individual patient and the blood glucose level).

Interaction

There are a number of medications that affect the need for insulin.

. Hypoglycemic effect of insulin is enhanced by oral hypoglycemic drugs, MAO inhibitors, non-selective beta-adrenoblockers, ACE inhibitors, sulfonamides, anabolic steroids, Carboanhydrase inhibitors, bromocriptine, octreotide, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, phenfluramine, lithium preparations, preparations containing ethanol.

The hypoglycemic effect of insulin is reduced by oral contraceptives, GCS, thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, calcium channel blockers, diazoxide, morphine, phenytoin, nicotine. Under the influence of reserpine and salicylates both weakening and enhancement of the drug action is possible.

Special Instructions

Biosulin H should not be used if the suspension does not turn white and uniformly turbid after shaking.

In insulin therapy, blood glucose levels should be monitored continuously.

Contraindications

– hypoglycemia;
– hypersensitivity to insulin or other components of Biosulin N.

Side effects

Metabolic disorders: hypoglycemic states (pale skin, increased sweating, palpitations, tremors, hunger, agitation, paresthesias in the mouth, headache). Severe hypoglycemia may lead to hypoglycemic coma.

Allergic reactions: rarely – skin rash, Quincke’s edema; in some cases – anaphylactic shock.

Local reactions: hyperemia, swelling and itching at the injection site; with prolonged use – lipodystrophy at the injection site.
Other: edema, transient refractive disorders (usually at the beginning of therapy).

Overdose

Symptoms: hypoglycemia may occur.

Treatment: mild hypoglycemia can be eliminated by the patient himself by taking sugar or carbohydrate-rich foods (diabetics are recommended to carry sugar, sweets, cookies or sweet fruit juice at all times). In severe cases, in case of loss of consciousness – intravenous administration of 40% dextrose solution; intravenous, p/c or intravenous – glucagon.

After recovery of consciousness, the patient is advised to take a carbohydrate-rich meal to prevent the recurrence of hypoglycemia.

Pregnancy use

There are no data on the use of the drug in pregnancy and during breast-feeding.