Bicillin-5, 1500000 units 10 ml

Pharmacotherapeutic group: Penicillin biosynthetic antibiotic

Pharmacokinetics

Indications

Active ingredient

Composition

How to take, the dosage

Intramuscularly.

Adults – 1200000 IU + 300000 IU once every 4 weeks.

Preschool children – 480000 IU + 120000 IU once every 3 weeks, children over 8 years – 960000 IU + 240000 IU once every 4 weeks.

The suspension is prepared using sterile water for injection, isotonic sodium chloride solution or 0.25-0.5% procaine (novocaine) solution.

Bicillin®-5 suspension is prepared aseptically, immediately before use (ex tempore): 5-6 ml of the solvent is slowly (at the rate of 5 ml in 20-25 seconds) injected into the vial with the drug under pressure. The contents of the vial is stirred and shaken along the longitudinal axis of the vial until a homogeneous suspension is formed. Bubbles are allowed on the surface of the suspension at the walls of the vial. Bicillin®-5 suspension is immediately after preparation deeply injected intramuscularly into the upper outer quadrant of the gluteal muscle. Stretching of the gluteal muscle after injection is not recommended. Delayed administration immediately after preparation alters the physical and colloidal properties of the suspension, which may result in difficulty in its movement through the syringe needle.

Interaction

Special Instructions

It should not be administered subcutaneously, intravenously, endolumbally, or in body cavities.

Inadvertent intravascular administration may cause transient feelings of depression, anxiety and visual disturbances (Wanier syndrome). In order to avoid accidental intravascular injection, aspiration is recommended prior to intramuscular injection in order to detect possible needle entry into the vessel.

In syphilis treatment, microscopic and serologic studies should be performed before starting therapy and then for 4 months. In connection with the development of fungal infections, it is advisable to simultaneously prescribe B-group vitamins and vitamin C, and, if necessary, antifungal drugs for systemic use. It should be taken into account that the use of insufficient doses or too early discontinuation of treatment often leads to the emergence of resistant strains of pathogens.

Contraindications

Hypersensitivity to the drug, benzylpenicillin and other beta-lactam antibiotics. Period of lactation.

With caution

Pregnancy, renal failure, history of allergy, bronchial asthma, pseudomembranous colitis.

Side effects

Allergic reactions: anaphylactic shock, anaphylactoid reactions, urticaria, fever, arthralgia, angioedema, erythema multiforme exudative, exfoliative dermatitis.

Laboratory findings: anemia, thrombocytopenia, leukopenia, hypocoagulation.

Others: stomatitis, glossitis.

Pregnancy use

Bicillin®-5 in small amounts penetrates through the placental barrier and into the mother’s milk. Administration during pregnancy is possible only when the estimated benefit to the mother exceeds the potential risk to the fetus.

It is recommended to stop breastfeeding if the drug has to be administered.