Betahistine-Vertex, tablets 16 mg 30 pcs

Betahistine is a histaminergic, improving microcirculation.

Pharmacodynamics

An agonist of H1-receptors of the inner ear vessels and an antagonist of H3-receptors of the vestibular CNS nuclei. By direct agonist effect on H1-receptors of the inner ear vessels and indirectly through the effect on H3-receptors it improves microcirculation and capillary permeability, normalizes the endolymph pressure in the labyrinth and cochlea, increases blood flow in the basilar artery.

It has a pronounced central effect, being an inhibitor of H3-receptor nuclei of the vestibular nerve. It improves conduction in neurons of vestibular nuclei at brainstem level.

The clinical manifestation of the above properties is reduction of the frequency and intensity of dizziness, reduction of tinnitus, improvement of hearing if it is reduced.

Pharmacokinetics

Absorbed rapidly, binding to plasma proteins is low. Time required to reachCmax is 3 hours.

It is almost completely excreted by the kidneys as a metabolite (2-pyridylacetic acid) within 24 hours. T1/2 is 3-4 hours.

Indications

Active ingredient

Composition

1 tablet contains:

Active substance:

Betahistine dihydrochloride16 mg;

Associates:

MCC;

lactose (milk sugar);

citric acid monohydrate;

How to take, the dosage

Internal, with meals. 1/2-1 tablets 3 times a day.

Improvement is usually seen at the beginning of therapy.

Stable therapeutic effect occurs after two weeks of treatment and can build up over several months of treatment. The treatment is long. The duration of therapy is determined individually.

Interaction

Antihistamines decrease the effect of betahistine when taken at the same time.

Special Instructions

Caution should be exercised in patients with a history of gastric or duodenal ulcer disease, in the second and third trimesters of pregnancy, and in children.

It should be taken into account that the desired clinical effect is achieved after several months of treatment.

In case of dyspeptic symptoms, betahistine is recommended to be taken with or after meals.

Contraindications

With caution:

Side effects

Gastrointestinal disorders, allergic reactions of the skin (skin rash, itching, urticaria), Quincke’s edema.

Overdose

Symptoms:Nausea, vomiting, seizures.

Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.

Pregnancy use

There is insufficient data to assess the effect of the drug during pregnancy and lactation.

In this regard, administration during pregnancy is not recommended.

Breastfeeding should be stopped during treatment.

Similarities