Betahistin-SZ, tablets 16 mg 60 pcs

Pharmacotherapeutic group:

Histamine drug.

ATC code: [N07CA01].

Pharmacodynamics:

Betahistine acts mainly on histamine H1- and H3-receptors of the inner ear and vestibular nuclei of the CNS. By means of direct agonist effect on H1-receptors of the inner ear vessels and indirectly through the effect on H3-receptors it improves microcirculation and capillary permeability, normalizes the endolymph pressure in the cochlea and labyrinth. At the same time betahistine increases blood flow in the basilar artery.

It has a pronounced central effect, being an inhibitor of H3-receptor nuclei of the vestibular nerve. It improves conductivity in neurons of vestibular nuclei at brain stem level. Clinical manifestation of the above properties is reduction of frequency and intensity of dizziness, decrease of tinnitus, improvement of hearing in case of its decrease.

Pharmacokinetics:

Absorbed quickly, binding to plasma proteins is low. Maximum concentration in plasma after 3 hours. The elimination half-life is in 3-4 hours. It is almost completely excreted by the kidneys as a metabolite (2-peridylacetic acid) within 24 hours.

Indications

treatment and prevention of vestibular vertigo of various origins;
syndromes including dizziness and headache, tinnitus, progressive hearing loss, nausea and vomiting;
Meniere’s disease or syndrome.

Pharmacological effect

Pharmacotherapeutic group:

histamine drug.

ATX code: [N07CA01].

Pharmacodynamics:

Betahistine acts mainly on histamine H1 and H3 receptors in the inner ear and vestibular nuclei of the central nervous system. Through a direct agonistic effect on the H1 receptors of the vessels of the inner ear, as well as indirectly through the effect on the H3 receptors, it improves microcirculation and capillary permeability, normalizes endolymph pressure in the labyrinth and cochlea. At the same time, betahistine increases blood flow in the basilar artery.

It has a pronounced central effect, being an inhibitor of H3 receptors in the nuclei of the vestibular nerve. Improves conductivity in the neurons of the vestibular nuclei at the level of the brain stem. The clinical manifestation of these properties is a decrease in the frequency and intensity of dizziness, a decrease in tinnitus, and an improvement in hearing if it is reduced.

Pharmacokinetics:

Absorbed quickly, binding to plasma proteins is low. Maximum concentration in blood plasma after 3 hours. The half-life is 3-4 hours. Almost completely excreted by the kidneys in the form of a metabolite (2-peridylacetic acid) within 24 hours.

Special instructions

Influence on the ability to drive a car and other mechanisms.

Active ingredient

Betahistine

Composition

active substance – betahistine dihydrochloride.

Excipients:

microcrystalline cellulose;

lactose (milk sugar);

citric acid;

colloidal silicon dioxide (Aerosil);

talc;

magnesium stearate;

sodium lauryl sulfate;

starch 1500 (pregelatinized starch).

Description:

tablets 16 mg – white or almost white, flat-cylindrical in shape, with a chamfer and a score.

Contraindications

– hypersensitivity to any of the components of the drug, children under 18 years of age (due to lack of data), pregnancy and lactation (due to lack of data);

With caution: peptic ulcer of the stomach or duodenum (including a history), pheochromocytoma, bronchial asthma. These patients should be monitored regularly during treatment;

– pregnancy and lactation period.

There is insufficient data to assess the effects of the drug during pregnancy and lactation. In this regard, use during pregnancy is not recommended. During treatment it is necessary to stop breastfeeding.

Side Effects

Gastrointestinal disorders, the appearance of hypersensitivity reactions on the skin (rash, itching, urticaria), Quincke’s edema.

Interaction

There are no known cases of interaction or incompatibility with other drugs.

Overdose

Symptoms: nausea, vomiting, convulsions.

Treatment: gastric lavage, taking activated carbon, symptomatic therapy.

Storage conditions

List B. In a dry place, protected from light, at a temperature not exceeding 25°C.

Shelf life

5 years. Do not use after expiration date.

Manufacturer

North Star NAO, Russia