Beclomethasone, aerosol 250 mcg/dose 200 doses

Beclomethasone dipropionate is a prodrug and has a weak tropism to GCS-receptors. Under the action of esterases it is converted into the active metabolite – beclomethasone-17-monopropionate (B-17-MP), which has a pronounced local anti-inflammatory effect. It reduces inflammation at the expense of chemotaxis substance formation (influence on “late” allergy reactions), inhibits development of “immediate” allergic reaction (caused by inhibition of arachidonic acid metabolites production and decrease of inflammatory mediators release from mast cells) and improves mucociliary transport.

Beclomethasone decreases the number of mast cells in the bronchial mucosa, it reduces epithelial edema, mucus secretion by bronchial glands, bronchial hyperresponsiveness, margin accumulation of neutrophils, inflammatory exudate and lymphokine production, decreases the macrophages migration, the intensity of infiltration and granulation. It increases the number of active beta-adrenoreceptors, restores the patient’s response to bronchodilators, allows reducing the frequency of their use. It has practically no resorptive effect after inhalation.

It does not arrest bronchospasm, therapeutic effect develops gradually, usually after 5-7 days of course use of beclometasone dipropionate.

Indications

Active ingredient

Composition

How to take, the dosage

Beclomethasone is for inhaled use only.

Beclomethasone is used regularly (even in the absence of symptoms), and the dose of beclomethasone dipropionate is adjusted for the clinical effect in each case.

In mild bronchial asthma, the inspiratory forced expiratory volume (PEF) or peak expiratory flow (PEF) is greater than 80% of appropriate values, with a PEF variation of less than 20%.

In a moderate course the SPR or PSV is 60-80% of the proper values, the daily variation of PSV is 20-30%.

In a severe course the ROS or PEF is 60 % of the proper values, the diurnal variability of PSV is more than 30 %.

When switching to high-dose inhaled beclomethasone dipropionate, many patients who receive systemic glucocorticosteroids will be able to reduce their dose, to stop them altogether.

The starting dose of Beclomethasone is determined by the severity of bronchial asthma. The daily dose is divided into several doses.

Depending on the patient’s individual response, the dose may be increased until clinical effect occurs or decreased to the lowest effective dose.

Children 4 to 12 years of age

The starting dose is 50 mcg 2 times daily. If necessary, the initial dose can be increased to 100 mcg 2 times a day. The maximum single dose is 200 micrograms.

The maximum daily dose is 400 mcg. The daily dose is divided into 2 to 4 doses.

Adults and children 12 years of age and older:

The recommended starting dose of the drug:

The treatment of bronchial asthma is based on a step-by-step approach: therapy is started according to the stage corresponding to the severity of the disease. Inhaled GCSs are prescribed in the second step of therapy.

Stage 2. Baseline therapy.

Beclomethasone dipropionate 100-400 mcg 2 times a day.

Stage 3. Baseline therapy.

The use of high-dose inhaled GCS or standard dose, but in combination with long-acting inhaled p-2-adrenomimetics.

Beclomethasone dipropionate in high dose – 800-1600 mcg/day, in some cases megadoses up to 2000 mcg/day.

Stage 4. Severe asthma.

Beclomethasone dipropionate in high dose – 800-1600 mcg/day, in some cases megadoses up to 2000 mcg/day.

Stage 5: Severe asthma.

Beclomethasone dipropionate in high dose (see steps 3 and 4).

Particular patient groups

There is no need to adjust the dose of Beclomethasone in the elderly or in patients with renal or hepatic impairment.

Missing a dose of the drug

If you accidentally miss an inhalation, the next dose should be taken at the correct time according to the treatment regimen.

Patient Instructions for Using an Inhaler

Check the performance of the inhaler before using it for the first time, also if you have not used it for a while, or if it has been cold and then warmed up to room temperature. To check this, remove the protective cap from the inhaler head, turn the can upside down with your index finger on the bottom of the can and your thumb on the top of the inhaler head, shake the can up and down and use your thumb and index finger to push the outlet on the inhaler head to the side. When the aerosol jet appears after the second squeeze, proceed as described below, starting with “Make sure there is no dust or dirt in the outlet tube.

You should do this on a regular basis:

In steps 3 and 4, take your time. It is important to breathe in as slowly as possible as you release the dose of medicine. Practice in front of a mirror at first. If you notice steam coming out of the corners of your mouth, start again with step 2.

Cleaning the inhaler.

The inhaler head should be cleaned at least once a week. Remove the inhaler nozzle from the cylinder and rinse it and the protective cap with warm water. Do not use hot water. Dry thoroughly, but do not use a heating device for this. Put the protective cap back on the inhaler nozzle and the protective cap back on the balloon. Do not dip the can in water.

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Similarities