Baralgin M, 500 mg/ml 5 pcs.

Baralgin is antispasmodic, analgesic, antipyretic, anti-inflammatory.

Blocks cyclooxygenase and reduces GH synthesis.

Pharmacokinetics

. After oral administration, it is hydrolyzed in the gastrointestinal tract to form the active metabolite, 4-methylaminoantipyrine (4-MMA), which is absorbed in the liver to 4-aminoantipyrine (4-AA), as well as pharmacologically inactive metabolites. After ingestion of 1 g of metamizole, 58% of 4-MMA and 48% of 4-AA are bound to plasma proteins. Effective therapeutic plasma concentration of 4-MMA is reached after 20-40 min, Cmax – after 2 h.

Indications

Active ingredient

Composition

1 ml of the solution contains metamizole sodium 500 mg;

How to take, the dosage

In colic patients the drug is administered intravenously 1 ampoule (5 ml) slowly over 5-8 minutes.

Repeated administration is possible after 6-8 hours.

The drug can be given intramuscularly, but it takes 20-30 minutes to take effect.

Interaction

Simultaneous use of metamizole with other non-narcotic analgesics may lead to a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, allopurinol impair metabolism of metamizole in the liver and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of metamizole. Sedatives and tranquilizers increase the analgesic effect of the drug. Concomitant use with chlorpromazine or other phenothiazine derivatives may lead to marked hyperthermia.

Rentgen contrast agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.

Methamisole displaces oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroid agents and indomethacin from binding to protein and increases their activity.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Because of the high likelihood of pharmaceutical incompatibility, the drug should not be mixed with other drugs in the same syringe.

Special Instructions

In patients suffering from bronchial asthma, taking the drug can provoke a seizure.

Contraindications

Side effects

Overdose

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, decreased BP, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, seizures, respiratory muscular paralysis.

Treatment: induction of vomiting, transprobe gastric lavage, saline laxatives, activated charcoal; carrying out of forced diuresis, hemodialysis, in case of convulsive syndrome – intravenous infusion of diazepam and fast acting barbiturates.

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