Azurix, 80 mg 30 pcs
€60.27 €50.23
Uric acid is the end product of purine metabolism in humans and is formed by the following reaction: hypoxanthine → xanthine → uric acid. Xanthine oxidase is a catalyst for both steps of this reaction. Febuxostat is a 2-arylthiazole derivative. Its therapeutic effect is associated with reduction of uric acid concentration in blood serum through selective inhibition of xanthine oxidase.
Indications
Treatment of chronic hyperuricemia in patients with diseases accompanied by deposits of urate crystals, including the presence of tophi and/or gouty arthritis in the present or in the history.
Active ingredient
Febuxostat
How to take, the dosage
Gout. The recommended dose of Azurix is 80 mg once daily orally, regardless of meals. If serum uric acid concentration exceeds 6 mg/dL (357 µmol/L) after 2-4 weeks of treatment, Azurix dose can be increased to 120 mg once a day.
The effect of this medicine comes on rather quickly, which makes it possible to re-test uric acid concentration after 2 weeks. The goal of treatment is to reduce uric acid concentration and maintain it at the level of < 6 mg/dL (357 μmol/L).
Interaction
Mercaptopurine/azathioprine. According to the mechanism of action of febuxostat consisting in the ability to inhibit xanthine oxidase, its simultaneous use with mercaptopurine/azathioprine is not recommended. Inhibition of xanthine oxidase may lead to increased plasma concentrations of both drugs, which may cause a toxic reaction. Studies of interaction of febuxostat with drugs that are metabolized by xanthine oxidase have not been conducted.
Contraindications
Hypersensitivity to the active substance or any other excipient of the drug.
Side effects
The most common adverse reactions in clinical trials (4072 patients using doses from 10 to 300 mg) and in post-marketing follow-up in patients with gout were gout exacerbations (attacks), liver dysfunction, diarrhea, nausea, headache, rashes, and edema. These reactions were mostly mild to moderate in severity. During post-marketing surveillance, there were reports of serious hypersensitivity reactions to febuxostat, some of them accompanied by systemic reactions.
Overdose
In case of overdose, symptomatic and supportive therapy is indicated.
Similarities
Adenuric, Febuxostat NW
Weight | 0.200 kg |
---|---|
Conditions of storage | Does not require special storage conditions. |
Manufacturer | Alium JSC, Russia |
Medication form | pills |
Brand | Alium JSC |
Related products
Buy Azurix, 80 mg 30 pcs with delivery to USA, UK, Europe and over 120 other countries.