AzitRus, 100 mg 4.2g 3 pcs.

Azitrus is a broad-spectrum antibiotic of the macrolide group, azalid. It acts bacteriostatically. By binding to 50S-subunit of ribosome it inhibits protein synthesis, inhibits bacterial growth and reproduction.

In high concentrations it produces bactericidal effect. It acts on extra- and intracellular pathogens.

Active against Gram-positive microorganisms: Streptococcus spp. (groups C, F and G, except erythromycin-resistant), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Staphylococcus epidermidis, Staphylococcus aureus; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp., as well as intracellular pathogens: Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium avium complex, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycinene is active against Gram-positive bacteria resistant to erythromycin.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

Active ingredient

Composition

1 package contains:

azithromycin (in the form of dihydrate) 100 mg;

excipients:

sodium citrate (sodium citric acid tri-substituted),

orange food flavoring,

sodium saccharinate,

collidone CL-M (crosspovidone),

sucrose.

How to take, the dosage

Overly 1 hour before or 2 hours after the meal once a day.

In adults: in case of infections of the upper and lower respiratory tract – 500 mg/day at 1 course over 3 days (course dose – 1.5 g).

Infections of skin and soft tissues: 1,000 mg/day on the first day at 1 administration and further
500 mg/day daily for 2 to 5 days (the course dose – 3 g).

In case of acute infections of urogenital organs (uncomplicated urethritis or cervicitis) – 1 g once.
In case of Lyme disease (borreliosis) to treat stage I (erythema migrans) – 1 g on the first day and 500 mg daily from the 2nd to 5th day (cumulative dose – 3 g).

In case of gastric and duodenal ulcer associated with Helicobacter pylori – 1 g/day for 3 days in combined anthelicobacter therapy.

In children with infections of upper and lower respiratory tract, skin and soft tissues the dose is 10 mg/kg of body weight once a day for 3 days (course dose – 30 mg/kg of body weight) or for 5 days: 10 mg/kg of body weight on the first day, then 5-10 mg/kg of body weight once a day for 4 days.
The following dosage regimens are recommended depending on the body weight of the child:

Form

Average daily (single) dose

5 kg
6 kg
7 kg
8 kg
9 kg
10-14 kg

Powder for suspension preparation 100 mg/5 ml

2.5 ml (50 mg)
3 ml (60 mg)
3.5 ml (70 mg)
4 ml (80 mg)
4.5 ml (90 mg)
5 ml (100 mg)

5 ml (200 mg)
7.5 ml (300 mg)
10 ml (400 mg)
prescribed doses for adults (500-1000 mg)

Interaction

In concomitant use antacids (aluminum- and magnesium-containing), ethanol and food slow down and decrease the absorption of azithromycin.

When co-administration of azithromycin in therapeutic doses with warfarin no changes of prothrombin time were noted, but taking into account that in interaction of macrolides with warfarin there may be increase of anticoagulant effect, careful control of prothrombin time is required in patients receiving this combination.

Concomitant use increases the concentration of digoxin in blood plasma. Concomitant use increases the toxic effects (vasospasm, dysesthesia) of ergotamine and dihydroergotamine.

Special Instructions

The drug is not taken with meals. In case of missing a dose, the missed dose should be taken as soon as possible, and the next ones should be taken at intervals of 24 hours.

A gap of at least 2 hours between doses of AzitRUS and antacids should be observed.

After discontinuation of the drug hypersensitivity reactions may persist in some patients, in these cases administration of specific therapy under medical supervision is recommended.

Contraindications

Side effects

Digestive system disorders: it is possible – diarrhea (5%), nausea (3%), abdominal pain (3%); ≤ 1% – flatulence, vomiting, melena, cholestatic jaundice, increased liver transaminases activity; in children – constipation, loss of appetite, gastritis, oral candidiasis, change of taste (≤ 1%).

Cardiovascular system: palpitations, chest pain (≤ 1%).

CNS disorders: dizziness, headache, somnolence; in children – headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disorders (≤ 1%).

Urinary system disorders: nephritis (≤ 1%).

Sexual system: vaginal candidiasis.

Allergic reactions: rash, urticaria, skin itching, angioedema; in children – conjunctivitis, itching, urticaria.

Others: asthenia, photosensitization.

Overdose

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: gastric lavage, symptomatic therapy

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