AzitRus, 100 mg 4.2g 3 pcs.

Azitrus is a broad-spectrum antibiotic of the macrolide group, azalid. It acts bacteriostatically. By binding to 50S-subunit of ribosome it inhibits protein synthesis, inhibits bacterial growth and reproduction.

In high concentrations it produces bactericidal effect. It acts on extra- and intracellular pathogens.

Active against Gram-positive microorganisms: Streptococcus spp. (groups C, F and G, except erythromycin-resistant), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Staphylococcus epidermidis, Staphylococcus aureus; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp., as well as intracellular pathogens: Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium avium complex, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycinene is active against Gram-positive bacteria resistant to erythromycin.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media);
scarlet fever;
lower respiratory tract infections (bacterial, including those caused by atypical pneumonia pathogens, exacerbation of chronic pneumonia, bronchitis);
infections of the skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses);
urinary tract infections (gonorrheal and non-gonorrheal urethritis);
infections of the female genital organs (cervicitis);
Lyme disease (borreliosis) in the initial stage (erythema migrans);
diseases of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy).

Pharmacological effect

Azitrus is a broad-spectrum antibiotic of the macrolide group, azalide. Acts bacteriostatically. By binding to the 50S ribosomal subunit, it inhibits protein synthesis and slows down the growth and reproduction of bacteria.

In high concentrations it has a bactericidal effect. Acts on extra- and intracellular pathogens.

Active against gram-positive microorganisms: Streptococcus spp. (groups C, F and G, except those resistant to erythromycin), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Staphylococcus epidermidis, Staphylococcus aureus; gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp., as well as intracellular pathogens: Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium avium complex, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycin is not active against gram-positive bacteria resistant to erythromycin.

Special instructions

The drug should not be taken with meals. If a dose is missed, the missed dose should be taken as soon as possible, and subsequent doses should be taken at intervals of 24 hours.

It is necessary to observe a break of at least 2 hours between doses of the drug AzitRus and antacid drugs.

After discontinuation of the drug, hypersensitivity reactions may persist in some patients; in such cases, it is recommended to prescribe specific therapy under medical supervision.

Active ingredient

Azithromycin

Composition

1 package contains:

azithromycin (in the form of dihydrate) 100 mg;

excipients:

sodium citrate (sodium citrate trisubstituted),

orange food flavoring,

sodium saccharinate,

Kollidon CL-M (crospovidone),

sucrose.

Contraindications

renal failure;
liver failure;
lactation (breastfeeding);
children up to 6 months (for suspension);
children under 3 years of age and/or body weight less than 25 kg (for capsules);
children under 12 years of age and/or body weight less than 50 kg (for film-coated tablets);
hypersensitivity to the components of Azitrus, as well as to other macrolides.

Side Effects

From the digestive system: possible – diarrhea (5%), nausea (3%), abdominal pain (3%); ≤ 1% – flatulence, vomiting, melena, cholestatic jaundice, increased activity of liver transaminases; in children – constipation, loss of appetite, gastritis, candidiasis of the oral mucosa, changes in taste (≤ 1%).

From the cardiovascular system: palpitations, chest pain (≤ 1%).

From the central nervous system: dizziness, headache, drowsiness; in children – headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disorders (≤ 1%).

From the urinary system: nephritis (≤ 1%).

From the reproductive system: vaginal candidiasis.

Allergic reactions: rash, urticaria, itching, angioedema; in children – conjunctivitis, itching, urticaria.

Other: asthenia, photosensitivity.

Interaction

With simultaneous use of antacids (aluminum- and magnesium-containing), ethanol and food slow down and reduce the absorption of azithromycin.

When azithromycin was used together in therapeutic doses with warfarin, no changes in prothrombin time were observed, however, given that the interaction of macrolides with warfarin may enhance the anticoagulant effect, when prescribing this combination to patients, careful monitoring of prothrombin time is necessary.

With simultaneous use, the concentration of digoxin in the blood plasma increases. With simultaneous use, the toxic effect (vasospasm, dysesthesia) of ergotamine and dihydroergotamine increases.

Overdose

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: gastric lavage, symptomatic therapy

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Storage conditions

The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25°C.

Shelf life

2 years.

Manufacturer

Sintez, Russia