Azelik Gel 15% 15 g

A preparation for external application.

It has bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis, reduces production of fatty acids contributing to acne. It reduces the formation of comedones. By influencing the keratinization process of epidermal cells, it suppresses the growth and activity of abnormal melanocytes that cause melasma-type hyperpigmentation. It has anti acne and depigmentation effect.

Pharmacokinetics

Assimilation

After application to the skin, it penetrates the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic bloodstream.

Metabolism and excretion

Part of absorbed acid is excreted by kidneys unchanged, part – as dicarboxylic acids (C7, C5) formed as a result of beta-oxidation.

Indications

— acne (acne vulgaris);

— rosacea.

Pharmacological effect

Preparation for external use.

It has bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis, reduces the production of fatty acids that contribute to acne. Reduces the formation of comedones. By influencing the process of keratinization of epidermal cells, it suppresses the growth and activity of abnormal melanocytes that cause hyperpigmentation such as melasma. Has an anti-acne, depigmenting effect.

Pharmacokinetics

Suction

After application to the skin, it penetrates into the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic circulation.

Metabolism and excretion

Part of the absorbed acid is excreted by the kidneys unchanged, part – in the form of dicarboxylic acids (C7, C5), formed as a result of beta-oxidation.

Special instructions

In cases of severe severe skin irritation in the first weeks of treatment, the gel can be used once a day; Short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug at the recommended dose should be resumed.

Avoid contact of the drug with the eyes, as well as the mucous membranes of the nose, lips and mouth; in case of accidental contact, rinse immediately with water. During treatment, it is necessary to protect the skin from the entire spectrum of solar radiation.

Active ingredient

Azelaic acid

Composition

Per 100 g:

azelaic acid in terms of 100% substance 15 g.

Excipients: benzoic acid – 0.1 g, methylpyrrolidone – 4 g, squalane – 1 g, propylene glycol – 8 g, disodium edetate – 0.1 g, sodium hydroxide – 0.25 g, dimethicone 100 cst – 1 g, macrogol cetostearyl ether – 1.4 g, carbomer interpolymer (type A) – 1.4 g, purified water – up to 100 g.

Contraindications

– hypersensitivity to the components of the drug.

The drug should be used with caution during pregnancy and lactation (breastfeeding).

Side Effects

On the part of the skin and subcutaneous fat: at the beginning of treatment, local irritation, hyperemia and peeling of the skin, burning, erythema, itching are possible, usually stopping during treatment; Possibly allergic skin reactions.

Interaction

Can be used in combination with other medications for the treatment of acne.

Overdose

Currently, no cases of drug overdose have been described.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Do not freeze.

Shelf life

2 years.

Manufacturer

Akrikhin JSC, Russia