Aviamarin, tablets 50 mg 5 pcs

Pharmacotherapeutic group: H1-histamine receptor blocker

ATX code: R06AX

Pharmacological properties

Pharmacodynamics: blocks histamine H1-receptors and M-cholinoreceptors of the central nervous system. Inhibits the vestibular apparatus of the inner ear, acting primarily on the otoliths, in high doses – on the semicircular canals. It has antiemetic, anorexigenic and sedative effects, eliminates dizziness.
Pharmacokinetics: after oral administration dimenhydrinate is well absorbed and distributed among organs and tissues. The action of the drug is seen 15-30 minutes later and lasts for 3-6 hours. About 78% of dimenhydrinate is bound to blood plasma proteins. Dimenhydrinate is metabolized in the liver and is almost completely eliminated from the body with urine within 24 hours. Small amounts are excreted with breast milk. The half-life (T1/2) of dimenhydrinate is about
3.5 hours.

Indications

– Motion sickness (seasickness, car sickness, air sickness).
– Prevention and treatment of symptoms of vestibular and labyrinth disorders (holo-dizziness, nausea, vomiting), except for symptoms caused by anticancer therapy.
– Meniere’s Disease.

Active ingredient

Composition

1 tablet contains: acting substance: dimenhydrinate 50 mg;

excipients: microcrystalline cellulose, povidone (collidone 30), crosspovidone, mannitol, colloidal silicon dioxide (aerosil), magnesium stearate.

How to take, the dosage

Internal, before meals.

Motion sickness (sea, automobile, air sickness):

children 3 to 6 years – 1/4-1/2 tablets 2-3 times a day;

children 7 to 12 years. – 1/2-1 tablet 2-3 times daily;

children over 12 years of age and adults – 1-2 tablets 2-3 times daily.

Prevention and treatment of symptoms of vestibular and labyrinth disorders (dizziness, nausea, vomiting), except for symptoms caused by anti-tumor therapy:

children 3 to 6 years – 1/4-1/2 tablets 2-3 times daily;

children 7 to 12 years – 1/2-1 tablet 2-3 times daily;

children over 12 years of age and adults – 1-2 tablets 2-3 times daily.

Meniere’s disease:

children from 3 to 12 years – 1/2 to 1 tablet 2-3 times a day; .

children over 12 years of age and adults – 1-2 tablets 2-3 times a day.

The maximum daily dose for adults should not exceed 7 tablets. For the prevention of kinetosis, 1-2 tablets should be taken 30 minutes before the trip. The duration of the drug and the possibility of repeating the course of treatment are subject to agreement with the doctor.

Interaction

Special Instructions

May affect reaction time when driving or operating other machinery

With regard to side effects, caution should be exercised when engaging in potentially hazardous activities that require increased attention and quick psychomotor reactions (including driving).

Synopsis

Contraindications

Hypersensitivity to the components of the drug, epilepsy, acute exudative and vesicular dermatoses, children under 3 years of age, pregnancy (I trimester), breast-feeding period.

With caution
Convulsive syndrome, closed-angle glaucoma, prostatic hyperplasia, bronchial asthma, cardiovascular disease, hyperthyroidism, stenotic peptic ulcer, pyloroduodenal obstruction and bladder cervical obstruction.

Side effects

Periodicity of adverse events: very frequently (≥1/10), frequently
(≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥1/10000, <1/1000), very rarely (<1/10000), unspecified frequency.

Disorders of the blood and lymphatic system: very rarely:hemolytic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia or pancytopenia.

Disorders of the immune system: frequently:anaphylactic shock.

Mental disorders: often:mood changes, anxiety, stiffness of movements; not infrequently:insomnia.

Nervous system disorders: frequently:drowsiness; not infrequently: impaired sense of balance, impaired concentration and impaired memory (more often in elderly patients), tremor, lack of coordination, confusion, hallucinations; frequently:headache, sleep disturbance, dizziness, orthostatic hypotension; very rarely: paradoxical CNS stimulation (especially in children).

Visual impairment: rarely: glaucoma, vision problems (dilated pupil, blurred vision or double vision).

Hearing and labyrinth disorders: frequently:tinnitus.

Disorder on the part of the heart: frequently:paced heart palpitations, tachycardia, and hypotension.

Disorders of the respiratory system, thorax and mediastinum: often:nasal congestion.

Gastrointestinal tract disorders: often:dry mouth, constipation, diarrhea, nausea, abdominal pain.

Liver and biliary tract disorders: unspecified frequency:disordered liver function (cholestatic jaundice).

Skin and subcutaneous tissue disorders: frequently:rash, redness.

Renal and urinary tract disorders: frequently:disordered urination (urinary retention due to anticholinergic action).

General disorders and disorders at the site of administration: frequently:edema (less commonly, Quincke’s edema).

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor!

Overdose

Symptoms of overdose: dry mouth, nose and throat, red face, slow and difficult breathing, confusion, in children – seizures, hallucinations. If you have these symptoms it is necessary to see a doctor urgently.

Treatment:Gastric lavage with activated charcoal suspension (20-30 g), administration of saline laxative (10-15 g sodium sulfate), symptomatic therapy, with convulsions in children – phenobarbital (5-6 mg/kg), diazepam.

Pregnancy use

Similarities