Atorvastatin, 10 mg 30 pcs
€4.84 €4.31
Pharmacological action is hypolipidemic.
Competitively selectively inhibits HMG-CoA reductase, which converts 3- hydroxy-3-methylglutaryl-CoA into mevalonic acid (precursor of sterols, including cholesterol). Triglycerides and cholesterol in the liver are incorporated into LPLONP, enter the plasma, and are transported to peripheral tissues. LDLNP is formed from LDLNP, which is catabolized by interaction with high-affinity LDL receptors. Elevated plasma levels of total cholesterol, LDL cholesterol, and apolipoprotein B contribute to atherosclerosis and are risk factors for cardiovascular disease, whereas increased levels of HDL are associated with reduced risk of cardiovascular complications.
Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and inhibits cholesterol synthesis in the liver by increasing the number of LDL receptors on the cell surface and enhances LDL uptake and catabolism. Suppresses the formation of LDL and the number of LDL particles. Reduces LDL-cholesterol levels in patients with homozygous familial hypercholesterolemia, which is usually resistant to therapy with hypolipidemic agents.
In most patients the effect is manifested 2 weeks after the start of therapy, the maximum effect develops by the 4th week and lasts for the whole period of treatment.
Toxic effect on CNS. Brain hemorrhage was observed in dogs when using atorvastatin for 3 months at a dose of 120 mg/kg/day, brain hemorrhage and formation of optic nerve vacuoles – in female dogs after 11 months of atorvastatin use at doses up to 280 mg/kg/day. The dose of 120 mg/kg/day created a systemic exposure approximately 16 times greater than that of the maximum therapeutic dose for humans (80 mg/day) in terms of AUC (0-24 h). In a two-year study, single tonic seizures were reported in two dogs (one at a dose of 10 mg/day, the other at a dose of 120 mg/day). There was no evidence of CNS damage in mice when atorvastatin was chronically administered for up to 2 years at doses up to 400 mg/day and in rats at doses up to 100 mg/day. These doses produced exposures 6-fold (mice) and 11-fold (rats) greater than those in humans at the recommended therapeutic dose of 80 mg per AUC(0-24 h).
Vascular damage in the CNS, characterized by perivascular hemorrhages, edema, and mononuclear cell infiltration of the perivascular spaces, has been reported in dogs given other drugs of this class. Chemically similar substances of the same class as atorvastatin caused dose-dependent degeneration of the optic nerve at a dose producing plasma concentrations 30 times greater than those in humans at the maximum recommended dose.
Carcinogenicity, mutagenicity, effects on fertility
In two-year studies of carcinogenicity in rats using doses of atorvastatin 10, 30 and 100 mg/kg/day, two rare tumors in muscle were found in females at the maximum dose: in one case it was rhabdomyosarcoma and in another, fibrosarcoma. This dose corresponded to systemic exposure values (plasma AUC0-24 h) 16 times greater than those in humans at an oral dose of 80 mg. In two-year studies of carcinogenicity in mice at doses of atorvastatin 100, 200, and 400 mg/kg/day, there was a significant increase in the incidence of liver adenoma at the maximum dose in males and liver carcinoma at the maximum dose in females. These cases were observed at a plasma AUC0 -24 h value approximately 6 times that of human exposure at an oral dose of 80 mg.
In vitro atorvastatin showed no mutagenic or clastogenic properties in the following tests (with/without metabolic activation): Ames test with Salmonella typhimurium and Escherichia coli, hypoxanthine-guanine phosphoribosyltransferase test and chromosome aberration test on Chinese hamster ovary cells. No in vivo mutagenicity was detected in a micronucleus test in mice.
In studies in rats at doses of atorvastatin up to 175 mg/kg (exposure 15 times higher than in humans) no adverse effects on fertility were found. When rats were injected with atorvastatin at a dose of 100 mg/kg/day (16 times the AUC in humans at a dose of 80 mg) for 3 months, aplasia and aspermia in the testicular appendages were recorded in 2 of 10 rats; testicular weight was significantly reduced at doses of 30 and 100 mg/kg and appendage weight was lower at the 100 mg/kg dose. Male rats that received atorvastatin at a dose of 100 mg/kg/day for 11 weeks before mating had decreased sperm motility and concentration, and the number of abnormal spermatozoa was increased. Atorvastatin had no adverse effects on sperm parameters and reproductive organs in dogs receiving it at doses of 10, 40, and 120 mg/kg for 2 years.
Atorvastatin is rapidly absorbed after oral administration, the degree of absorption increases in proportion to increasing dose, Cmax is reached within 1-2 hours. Absolute bioavailability is approximately 14%, systemic availability with respect to HMG-CoA reductase inhibition is approximately 30%. Low systemic availability is due to presystemic metabolism in the gastrointestinal mucosa and/or during “first passage” through the liver. Mean volume of distribution of atorvastatin is approximately 381 l. Binding to plasma proteins is ≥98%. Blood/plasma level ratio is approximately 0.25, which indicates poor atorvastatin penetration into erythrocytes. In the liver atorvastatin is extensively metabolized with the participation of cytochrome P450 isoenzyme CYP3A4 to form ortho- and parahydroxylated derivatives and various beta-oxidation products. In vitro, ortho- and parahydroxylated metabolites have an inhibitory effect against HMG-CoA reductase, comparable with that of atorvastatin. The inhibitory effect against HMG-CoA reductase is approximately 70% determined by the activity of circulating metabolites. Atorvastatin and its metabolites are excreted mainly with bile after hepatic and/or extrahepatic metabolism (not subjected to marked hepatic recirculation). T1/2 atorvastatin is 14 h. Due to the presence of active metabolites, inhibitory activity against HMG-CoA reductase persists for about 20-30 hours. Less than 2% of the oral dose of atorvastatin is detected in urine. It is not excreted during hemodialysis.
Peculiarities of pharmacokinetics in specific groups of patients
In elderly patients plasma concentrations of atorvastatin are higher (approximately 40% for Cmax and 30% for AUC) than in elderly patients. Cmax values are 20% higher in women and AUC values are 10% lower (not clinically relevant). Renal diseases do not influence on plasma concentrations of atorvastatin or its effect on lipid metabolism parameters. In patients with alcoholic cirrhosis concentrations of atorvastatin are significantly increased: in mild degree of liver dysfunction (Child Pugh Class A) – 4 times (both Cmax and AUC), in moderate degree of dysfunction (Child Pugh Class B) – Cmax 16 times, AUC – 11 times higher than normal.
Indications
Primary hypercholesterolemia (heterozygous familial and non-familial hypercholesterolemia, Fredrickson type IIa), combined (mixed) hyperlipidemia (Fredrickson types IIb and III), Dysbetalipoproteinemia (Fredrickson type III) (as an adjunct to diet), familial endogenous hypertriglyceridemia (Fredrickson type IV), resistant to dietary treatment methods. Homozygous hereditary hypercholesterolemia (as an adjunct to hypolipidemic therapy, including autohemotransfusion of LDL-purified blood). Diseases of the cardiovascular system (including patients without clinical manifestations of CHD, but with increased risk factors of its occurrence – age over 55 years, nicotine addiction, arterial hypertension, genetic predisposition), including against the background of dyslipidemia – secondary prevention in order to reduce the total risk of death, myocardial infarction, stroke, repeated hospitalization for angina and the need for revascularization.
Active ingredient
Atorvastatin
Composition
1 film-coated tablet contains:
the active substance: atorvastatin calcium trihydrate – 10.85 mg, which corresponds to 10 mg of atorvastatin;
excipients: calcium carbonate, microcrystalline cellulose, milk sugar (lactose), starch 1500, colloidal silica (aerosil), magnesium stearate, opadray II (polyvinyl alcohol, macrogol (polyethylene glycol), talc, titanium dioxide).
How to take, the dosage
Ingestion.
Before prescribing Atorvastatin, a standard hypolipidemic diet should be recommended for the patient, which the patient should continue to follow during the entire period of therapy.
The initial dose is on average 10 mg/day. The dose varies from 10 to 80 mg/day.
The drug can be taken at any time of the day with food or regardless of the time of meals. The dose is adjusted with regard to baseline cholesterol/LDL levels, the goal of therapy, and individual effect. At the beginning of treatment and/or during dose increase of Atorvastatin it is necessary to monitor plasma lipid levels every 2-4 weeks and adjust the dose accordingly.
In order to ensure the following dosing regimen of the drug it is possible to use Atorvastatin in other dosage forms: film-coated tablets 10 mg and 20 mg. The maximum daily dose of the drug is 80 mg.
In concomitant use with cyclosporine, the daily dose of Atorvastatin should not exceed 10 mg.
Primary hypercholesterolemia and mixed hyperlipidemia. In most cases, it is sufficient to prescribe a dose of 10 mg of Atorvastatin once daily. Significant therapeutic effect is observed after 2 weeks, and the maximum therapeutic effect is usually observed after 4 weeks. With long-term treatment this effect is maintained.
Patient special groups
Kidney function disorders. Administration of the drug in patients with renal insufficiency and renal diseases does not influence on plasma levels of Atorvastatin or degree of cholesterol/LDL decrease with its use, therefore no change of drug dose is required.
Hepatic disorders. In case of hepatic insufficiency, the dose should be reduced.
Elderly patients. No differences in safety, efficacy or achievement of hypolipidemic therapy goals have been noted when using the drug in elderly patients compared to the general population.
Interaction
The risk of myopathy during treatment with statins is increased when used in combination with cyclosporine, fibrates, erythromycin, nicotinic acid in lipid-lowering doses, strong CYP3A4 inhibitors (including clarithromycin, HIV protease inhibitors, itraconazole).
When using atorvastatin in combination with CYP3A4 isoenzyme inhibitors (e.g. cyclosporine, macrolide antibiotics – erythromycin and clarithromycin; itraconazole, HIV protease inhibitors) may increase plasma concentrations of atorvastatin (atorvastatin is metabolized with the participation of CYP3A4); special caution should be exercised when using atorvastatin in combination with the above-mentioned drugs (see “Cautionary notes. See “Special Precautions”).
In combined use of atorvastatin in dose of 40 mg and itraconazole in dose of 200 mg once a day it was stated 3-fold increase of Atorvastatin AUC in comparison with AUC in monotherapy.
Concomitant use of atorvastatin with protease inhibitors (lopinavir/ritonavir, ritonavir/saquinavir) was accompanied by increased plasma concentration of atorvastatin. In concurrent administration of atorvastatin in dose 40 mg and lopinavir+ritonavir combination (in dose 400/100 mg 2 times per day) it was stated 5.9 times increased AUC of atorvastatin in comparison with AUC during monotherapy. When using atorvastatin at a dose of 40 mg with a combination of ritonavir + saquinavir (in a dose of 400/400 mg 2 times a day) its AUC was increased by 3.9 times.
Antacids decrease the concentration of atorvastatin by 35% (effect on LDL cholesterol is not changed).
Recurrent administration of digoxin and atorvastatin increases Css of digoxin by approximately 20% (patients should be monitored).
In coadministration of atorvastatin and oral contraceptives, the AUC of norethindrone and ethinylestradiol is increased by approximately 30 and 20% (this effect should be considered when choosing an oral contraceptive for a woman receiving atorvastatin).
In concomitant administration with erythromycin (CYP3A4 inhibitor) plasma concentration of atorvastatin is increased by about 40%. Hypolipidemic effect of combination of atorvastatin and colestipol is superior for each drug separately. Concomitant use with drugs that reduce concentration or activity of endogenous steroid hormones (including ketoconazole, spironolactone, cimetidine), increases the risk of reducing endogenous steroid hormone production (caution should be observed).
Concomitant oral administration of atorvastatin and suspension containing magnesium and aluminum hydroxide decreased plasma concentrations of atorvastatin by approximately 35%, but the degree of decrease in cholesterol/LDL levels did not change.
Special Instructions
Before starting therapy with Atorvastatin, a patient should be prescribed a standard hypocholesterolemic diet, which should be followed during the whole period of treatment.
Use of HMG-CoA reductase inhibitors to reduce blood lipid levels may lead to changes in biochemical parameters reflecting liver function. Liver function should be monitored before the start of therapy, at 6 weeks, 12 weeks after the start of Atorvastatin administration and after each dose increase as well as periodically, e.g., every 6 months. Elevation of serum hepatic enzymes activity may be observed during Atorvastatin therapy. Patients with increased enzyme levels should be monitored until enzyme levels return to normal. If values of alanine aminotransferase (ALT) or asparagine aminotransferase (AST) are more than 3 times higher than the upper allowable limit, it is recommended to reduce the dose of Atorvastatin or discontinue treatment.
Atorvastatin should be used with caution in patients who abuse alcohol and/or have liver disease. Active liver disease or persistent increase in aminotransferase activity of unclear genesis are contraindications to Atorvastatin administration.
Treatment with Atorvastatin may cause myopathy. Diagnosis of myopathy (pain and weakness in muscles combined with an increase in creatine phosphokinase (CPK) activity more than 10 times the upper limit of normal) should be discussed in patients with widespread myalgia, muscle soreness or weakness and/or marked increase in CPK activity. Patients should be warned to inform their physician immediately of unexplained muscle pain or weakness if accompanied by malaise or fever. Atorvastatin therapy should be discontinued in case of marked increase in CPK activity or in the presence of confirmed or suspected myopathy. Risk of myopathy during treatment with other drugs of this class was increased with concomitant use of cyclosporine, fibrates, erythromycin, nicotinic acid or azole antifungal agents. Many of these drugs inhibit cytochrome P450 3A4-mediated metabolism and/or drug transport. Atorvastatin is biotransformed by CYP 3A4. Prescribing Atorvastatin in combination with fibrates, erythromycin, immunosuppressive agents, azole antifungal agents or nicotinic acid in hypolipidemic doses, the expected benefits and risks of treatment should be carefully weighed and patients should be regularly observed to detect muscle pain or weakness, especially during the first months of treatment and during periods of increasing doses of any drug. In such situations, periodic determination of CPK activity may be recommended, although such monitoring does not prevent the development of severe myopathy.
Cases of rhabdomyolysis with acute renal failure due to myoglobinuria have been described when using Atorvastatin, as well as other drugs of this class. Atorvastatin therapy should be temporarily discontinued or completely discontinued in case of signs of possible myopathy or presence of risk factor of renal failure during rhabdomyolysis (for example, severe acute infection, arterial hypotension, serious operation, trauma, severe metabolic, endocrine and electrolyte disorders and uncontrolled convulsions).
Before starting therapy with Atorvastatin, an attempt should be made to achieve control of hypercholesterolemia through adequate diet therapy, increasing physical activity, reducing body weight in obese patients and treatment of other conditions.
Patients should be warned that they should immediately consult a physician if unexplained muscle pain or weakness occurs, especially if it is accompanied by malaise or fever.
Contraindications
Hypersensitivity, active liver disease (including active chronic hepatitis, chronic alcoholic hepatitis), increased liver transaminase activity (more than 3 times the upper limit of normal) of unknown genesis, liver failure, liver cirrhosis of any etiology, pregnancy and lactation.
Side effects
In controlled clinical trials (n=2502) less than 2% of patients discontinued treatment due to atorvastatin-induced adverse effects. The most common adverse effects associated with atorvastatin administration were constipation, flatulence, dyspepsia, and abdominal pain.
Nervous system and sense organs: ≥2% – headache, asthenic syndrome, insomnia, dizziness;
Cardiovascular system: ≥2% – chest pain;BP, phlebitis, arrhythmia, angina, anemia, lymphadenopathy, thrombocytopenia.
Respiratory system: ≥2% – sinusitis, pharyngitis, bronchitis, rhinitis;
Gastrointestinal system disorders: ≥2% – abdominal pain, constipation or diarrhea, dyspepsia, flatulence, nausea;
Musculoskeletal disorders: ≥2% – arthralgia, myalgia, arthritis;
Urinary system disorders: ≥2% – urogenital infections, peripheral edema;
Skin disorders:
Allergic reactions: ≥2% – skin rash;
Other: ≥2% – infections, accidental trauma, flu-like syndrome, back pain; ALT, elevated ALT or AST, gout exacerbation.
Side effects noted in post-marketing studies with atorvastatin therapy: anaphylaxis, angioneurotic edema, bullous rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), rhabdomyolysis, tendon rupture.
Overdose
Treatment: there is no specific antidote, symptomatic therapy is carried out.
Hemodialysis is ineffective.
Similarities
Liprimar, Atoris, Tulip, Atorvastatin, Torvacard, Atorvastatin NW , Atorvastatin-Teva
Weight | 0.015 kg |
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Shelf life | 2 years. |
Conditions of storage | Store in a dry place protected from light, out of the reach of children, at a temperature of 15 C to 30 C. |
Manufacturer | Ozon, Russia |
Medication form | pills |
Brand | Ozon |
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