Aspirin Express, 500 mg 12 pcs

Aspirin Express belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and has analgesic, antipyretic and anti-inflammatory effects.

Indications

Symptomatic treatment:

Elevated body temperature in colds and other infectious and inflammatory diseases (adults and children over 15 years).

Active ingredient

Composition

1 tablet for making an effervescent drink contains:

Active substances

Acetylsalicylic acid – 500 mg.

Associates

Microcrystalline cellulose,

Corn starch.

How to take, the dosage

To the mouth, after meals, dissolving the tablet in a glass of water.

The single dose is 1-2 effervescent tablets. The maximum single dose is 2 effervescent tablets. The maximum daily dose should not exceed 6 tablets.

The intervals between doses should be at least 4 hours.

The duration of treatment without consulting a physician should not exceed 5 days when prescribed as a pain reliever and 3 days when prescribed as an antipyretic.

Interaction

Augmented drug toxicity

Augmented toxicity of methotrexate, the effects of narcotic analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole), triiodothyronine, reserpine.

Allows the effects of uricosuric drugs

Allows the effects of uricosuric drugs (benzbromaron, sulfinpyrazone ), hypotensive agents and diuretics (spironolactone , furosemide ).

Enhances plasma concentrations of the following drugs

Enhances plasma concentrations of digoxin, barbiturates and lithium preparations.

Worsens the damaging effects on the gastrointestinal mucosa of the drugs

Glucocorticosteroids, alcohol and alcohol-containing drugs increase the damaging effects on the gastrointestinal mucosa and increase the risk of gastrointestinal bleeding.

Deterioration of absorption of acetylsalicylic acid

Antacids containing magnesium and/or aluminum hydroxide slow down and impair absorption of acetylsalicylic acid.

Special Instructions

Co-administration with other NSAIDs and glucocorticoids is undesirable. 5-7 days before surgical intervention it is necessary to cancel the intake (to reduce bleeding during surgery and in the postoperative period).

The likelihood of developing NSAID gastropathy is reduced when prescribed after meals, using tablets with buffer supplements or coated with a special enteric coating. The risk of hemorrhagic complications is considered to be the lowest when used in dosage forms.

It should be taken into account that in predisposed patients acetylsalicylic acid (even in small doses) reduces excretion of uric acid from the body and may cause the development of an acute attack of gout.

With prolonged therapy, it is recommended that regular blood tests and fecal occult blood tests be performed. Due to the observed cases of hepatogenic encephalopathy, it is not recommended for the management of febrile syndrome in children.

Contraindications

Side effects

Central nervous system disorders

Dizziness, tinnitus (usually a sign of overdose).

Hemorrhagic syndrome, thrombocytopenia.

Urinary system disorders

When used in high doses – hyperoxaluria and formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys.

Allergic reactions

Skin rash, anaphylactic reactions, bronchospasm, Quincke’s edema.

Gastrointestinal tract disorders

Abdominal pain, nausea, vomiting , overt (black stool, bloody vomiting) or latent signs of gastrointestinal bleeding, which may lead to Iron deficiency anemia, erosive ulcerative lesions, including with perforation, of the gastrointestinal tract.

Rarely – liver function disorders (increased liver transaminases, AST , ALT ).

If these symptoms occur, it is recommended to stop taking the drug and see a physician immediately.

Overdose

Symptoms: CNS agitation, dizziness, severe headache, decreased hearing acuity, visual impairment, nausea, vomiting, increased respiration.

In the late stage of poisoning: drowsiness, seizures, anuria, depression of consciousness up to coma, respiratory failure, disorders of water-electrolyte metabolism.

treatment: Contact a physician. Treatment should be carried out in the conditions of a specialized department. For signs of poisoning – induction of vomiting or gastric lavage, administration of activated charcoal and laxatives.

Pregnancy use

The use of high doses of salicylates in the first trimester of pregnancy is associated with an increased incidence of fetal defects (cleft palate, heart defects). In the second trimester of pregnancy, salicylates may be prescribed only with consideration of risk-benefit assessment. Prescribing salicylates in the third trimester of pregnancy is contraindicated.

Salicylates and their metabolites penetrate into breast milk in small amounts.

Inadvertent administration of salicylates during lactation is not accompanied by the development of adverse reactions in the baby and does not require discontinuation of breastfeeding. However, breastfeeding should be discontinued when prolonged use or when prescribed in high doses.

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