Aspirin Express, 500 mg 12 pcs

Aspirin Express belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and has analgesic, antipyretic and anti-inflammatory effects.

Indications

Symptomatic treatment:

Toothache.
Sore throat.
Headache.
Muscle and joint pain.
Pain during menstruation. Back pain.
Mild pain due to arthritis.

Increased body temperature during colds and other infectious and inflammatory diseases (in adults and children over 15 years of age).

Pharmacological effect

Aspirin Express belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and has analgesic, antipyretic and anti-inflammatory effects.

Special instructions

Concomitant use with other NSAIDs and glucocorticoids is undesirable. 5–7 days before surgery, it is necessary to stop taking the drug (to reduce bleeding during surgery and in the postoperative period).

The likelihood of developing NSAID gastropathy is reduced when prescribed after meals, using tablets with buffer additives or coated with a special enteric coating. The risk of hemorrhagic complications is considered to be lowest when used in dosages.

It should be borne in mind that in predisposed patients, acetylsalicylic acid (even in small doses) reduces the excretion of uric acid from the body and can cause the development of an acute attack of gout.

During long-term therapy, it is recommended to regularly perform blood tests and examine stool for occult blood. Due to observed cases of hepatogenic encephalopathy, it is not recommended for the relief of febrile syndrome in children.

Active ingredient

Acetylsalicylic acid

Composition

1 tablet for making an effervescent drink contains:

Active ingredients

Acetylsalicylic acid – 500 mg.

Excipients

Microcrystalline cellulose,

corn starch.

Pregnancy

The use of large doses of salicylates in the first trimester of pregnancy is associated with an increased incidence of fetal defects (cleft palate, heart defects). In the second trimester of pregnancy, salicylates can be prescribed only after assessing the risks and benefits. The administration of salicylates in the third trimester of pregnancy is contraindicated.

Salicylates and their metabolites pass into breast milk in small quantities.

Accidental intake of salicylates during lactation is not accompanied by the development of adverse reactions in the child and does not require cessation of breastfeeding. However, with long-term use or high doses, breastfeeding should be discontinued.

Contraindications

Asthma caused by taking salicylates or other NSAIDs in combination with nasal polyps.
Combined use of methotrexate at a dose of 15 mg per week or more.
Severe liver or kidney dysfunction.
Hypersensitivity to acetylsalicylic acid and other NSAIDs.
Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase).
Gastrointestinal bleeding.
Hemorrhagic diathesis.
Hemophilia, thrombocytopenia.
Glucose-6-phosphate dehydrogenase deficiency.
Pregnancy (I and III trimester).
Breastfeeding period.
Children’s age (up to 15 years).

Use caution in the following cases:

With concomitant therapy with anticoagulants.
Gout.
Peptic ulcer of the stomach and/or duodenum (history).
Erosive gastritis.
Tendency to gastrointestinal bleeding.
Hypoprothrombinemia.
Hypovitaminosis K.
Anemia.
Conditions predisposing to fluid retention in the body (including cardiac dysfunction, arterial hypertension).
Thyrotoxicosis.

Side Effects

From the central nervous system

Dizziness, tinnitus (usually signs of overdose).

From the hematopoietic system

Hemorrhagic syndrome, thrombocytopenia.

From the urinary system

When used in high doses – hyperoxaluria and the formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys.

Allergic reactions

Skin rash, anaphylactic reactions, bronchospasm, Quincke’s edema.

From the gastrointestinal tract

Abdominal pain, nausea, vomiting, obvious (black stool, bloody vomiting) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions, including perforation, of the gastrointestinal tract.

Rarely – liver dysfunction (increased liver transaminases, AST, ALT).

If such symptoms appear, it is recommended to stop taking the drug and immediately consult your doctor.

Interaction

Increased drug toxicity

Increases the toxicity of methotrexate, the effects of narcotic analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole), triiodothyronine, reserpine.

Reduces the effects of uricosuric drugs

Reduces the effects of uricosuric drugs (benzbromarone, sulfinpyrazone), antihypertensive drugs and diuretics (spironolactone, furosemide).

Increases plasma concentrations of the following drugs

Increases the concentration of digoxin, barbiturates and lithium drugs in the blood plasma.

Strengthens the damaging effect of drugs on the mucous membrane of the gastrointestinal tract

Glucocorticosteroids, alcohol and alcohol-containing drugs increase the damaging effect on the mucous membrane of the gastrointestinal tract and increase the risk of developing gastrointestinal bleeding.

Impaired absorption of acetylsalicylic acid

Antacids containing magnesium and/or aluminum hydroxide slow down and impair the absorption of acetylsalicylic acid.

Overdose

Symptoms: central nervous system stimulation, dizziness, severe headache, decreased hearing acuity, blurred vision, nausea, vomiting, increased breathing.

In the late stage of poisoning: drowsiness, convulsions, anuria, depression of consciousness up to coma, respiratory failure, disturbances in water and electrolyte metabolism.

Treatment: You should consult a doctor. Treatment should be carried out in a specialized department. If there are signs of poisoning, induce vomiting or perform gastric lavage, prescribe activated charcoal and a laxative.

Storage conditions

Store in a dry place, protected from light, at temperatures below 25°C.

Keep out of the reach of children.

Do not use after expiration date.

Shelf life

3 years.

Manufacturer

Bayer Bitterfeld GmbH, Germany