Ascorbic acid, 100 mg/ml 2 ml 10 pcs

Ascorbic acid has pronounced reducing properties, is involved in the regulation of carbohydrate metabolism, redox processes, blood coagulation, normalization of capillary permeability, tissue regeneration, synthesis of steroid hormones, collagen, procollagen.

Pharmacokinetics

Binding with plasma proteins – 25%. The concentration of ascorbic acid in plasma is normally about 10 – 20 µg/ml. It penetrates easily into leukocytes, platelets and then into all tissues; the highest concentration is in glandular organs, leukocytes, liver and eye lens; penetrates through placenta.

The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, the concentration in leukocytes decreases later and more slowly and is considered a better criterion for assessing deficiency than the concentration in plasma.

It is metabolized primarily in the liver to deoxyascorbic acid and then to oxalic acid and ascorbate-2-sulfate.

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Indications

Composition

How to take, the dosage

It is used as prescribed by the doctor.

Ascorbic acid is prescribed orally (after meals), intramuscularly or intravenously.

For preventive purposes it is prescribed for adults 0.05 g-0.1 g a day; during pregnancy, during the postpartum period and in case of low content of vitamin C in the milk of nursing women the dose is 0.3 g a day for 10-15 days, after that 0.1 g a day during the whole lactation period prophylactically.

In children 0.025 g 2 – 3 times a day prophylactically.

Therapeutic doses for adults are taken orally – 0,05-0,1 g 3-5 times a day; for children – 0,05-0,1 g 2-3 times a day.

Therapeutic doses for adults when administered parenterally are 1-3 ml of 5% solution (2-6 ml of 2.5% solution) daily.

In children 1-2 ml of 5% solution (2-4 ml of 2.5% solution) is administered parenterally a day.

The course of treatment depends on the nature and course of the disease.

Interaction

Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicillin, warfarin.

Enhances blood concentrations of benzylpenicillin and tetracyclines; at a dose of 1 g / day increases the bioavailability of ethinylestradiol (including those included in oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants.

Concomitant use with acetylsalicylic acid increases urinary excretion of ascorbic acid and decreases excretion of acetylsalicylic acid.

It increases the risk of crystalluria during treatment with salicylates and short-acting sulfonamides, slows renal excretion of acids, increases excretion of drugs with alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives. Increases total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Drugs of the quinoline series, calcium preparations, salicylates, glucocorticosteroids with long-term use deplete ascorbic acid reserves.

In concomitant use reduces the chronotropic effect of isoprenaline.

In long-term use or use in high doses may prevent interaction between disulfiram and ethanol. In high doses increases excretion of mexiletine by the kidneys. Barbiturates and primidone increase ascorbic acid excretion with urine.

Decreases therapeutic effects of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubal reabsorption of amphetamine and tricyclic antidepressants.

Special Instructions

Because of the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, adrenal function and blood pressure should be monitored. High doses of ascorbic acid increase oxalate excretion, contributing to kidney stone formation.

In newborns whose mothers have taken high doses of ascorbic acid and in adults who have taken high doses, “ricochet” scurvy can occur.

In prolonged use of high doses it is possible suppression of pancreatic insular apparatus function, therefore it should be regularly monitored during treatment. In patients with increased iron content in the body ascorbic acid should be used in minimal doses.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood and urine glucose, bilirubin, activity of “liver” transaminases and lactate dehydrogenase).

Impact on driving and operating machinery

At the time of treatment, caution should be exercised while driving motor transport and engaging in potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity.

In long-term use in high doses (more than 500 mg):

With caution: sideroblast anemia, urolithiasis.

Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.