Artra, 30 pcs.

Artra stimulates the regeneration of cartilage tissue.
Glucosamine and chondroitin sulfate are involved in the synthesis of connective tissue, contributing to the prevention of cartilage destruction processes and stimulating tissue regeneration.
Introduction of exogenous glucosamine increases the production of cartilage matrix and provides nonspecific protection against chemical damage to cartilage. Glucosamine in the form of the sulfate salt is a precursor of hexosamine, and the sulfate anion is necessary for the synthesis of glycosaminoglycans. Other possible functions of glucosamine are to protect the damaged cartilage from the metabolic destruction caused by NSAIDs and GCS, as well as its own moderate anti-inflammatory effect.
Chondroitin sulfate, whether absorbed intact or as individual components, serves as an additional substrate for the formation of a healthy cartilage matrix. It stimulates the formation of hyaluronone, synthesis of proteoglycans and type II collagen, and also protects hyaluronone from enzymatic degradation (by inhibiting the activity of hyaluronidase) and from the damaging effects of free radicals, maintains the viscosity of synovial fluid, stimulates mechanisms of cartilage repair and inhibits the activity of those enzymes that break down cartilage (elastase, hyaluronidase). In the treatment of osteoarthritis relieves symptoms and reduces the need for NSAIDs.
Pharmacokinetics: Glucosamine: bioavailability at oral administration – 25% (effect of “first passage” through the liver).
Distributed in tissues: the highest concentrations are found in the liver, kidneys and joint cartilage. About 30% of the dose taken persists in bone and muscle tissue for a long time.
It is excreted mainly with the urine unchanged; partially – in the feces. T1/2 – 68 h.
Chondroitin sulfate: when administered orally in a single dose of 0.8 g (or 2 times daily in a dose of 0.4 g) the concentration in plasma increases sharply for 24 hours. Absolute bioavailability is 12%. About 10 and 20% of the dose taken is absorbed as high and low molecular weight derivatives, respectively. The apparent volume of distribution is about 0.44 ml/g.
Metabolized by desulfurization. It is excreted with the urine. T1/2 – 310 min.

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Indications

Osteoarthritis of the peripheral joints and spine.

Active ingredient

Composition

Active ingredients:
Glucosamine hydrochloride 500 mg
Chondroitin sulfate sodium 500 mg
Excipients: calcium phosphate displaced, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate.
Shell:
Hydroxypropyl methylcellulose, titanium dioxide (E171), triacetin.

How to take, the dosage

Ingestion. Adults and children over 15 years old take 1 tablet of Artra 2 times daily during the first three weeks; 1 tablet once daily during the next weeks and months. Sustained therapeutic effect is achieved when taking the drug for at least 6 months.

Interaction

It increases absorption of tetracyclines, reduces the effect of semisynthetic penicillins. The drug is compatible with NSAIDs and GCS.

Contraindications

Hypersensitivity, severe renal dysfunction.

With caution: bleeding or bleeding tendency, bronchial asthma, diabetes mellitus.

With caution.

Side effects

Glucosamine: minor gastrointestinal dysfunction (epigastric pain, flatulence, diarrhea, constipation), dizziness, skin allergic reactions are possible.
Chondroitin: allergic reactions.

Overdose

Symptoms: cases of overdose are unknown.
Treatment gastric lavage, symptomatic therapy.

Pregnancy use

It is not recommended for use during pregnancy and lactation.

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