Arthrodarin, 50 mg capsules 30 pcs

Pharmgroup:

The drug used in inflammatory and inflammatory-dystrophic diseases of the musculoskeletal system.

Pharm Action:

Artrodarin is an anti-inflammatory drug, an inhibitor of the synthesis and activity of interleukin-1 (IL-1). IL-1 plays an important role in the development of inflammation, degradation and subsequent destruction of cartilage in osteoarthritis.

Diacerein also inhibits the action of other cytokines that cause inflammation, including IL-6, TNFα. Diacerein also inhibits the formation of metalloproteases (collagenase, elastase), which are involved in the process of cartilage damage. With long-term use diacerein stimulates the synthesis of proteoglycans and has no effect on the synthesis of prostaglandins.

Pharmacokinetics:

Absorption and metabolism

After oral administration of Arthrodarin, diacerein is rapidly absorbed from the GI tract and is completely deacetylated to Rein. Administration of the drug simultaneously with food increases bioavailability by 25%. Cmax of reine in plasma is reached after 144 min. Cmax is 3.15 mg/l after a single dose of 50 mg. When multiple doses of the drug Cmax of Rein is increased due to cumulation.

Distribution and excretion

The binding of rein with albumin is almost 100%. Rein penetrates the HEB and the placental barrier. T1/2 is 255 min. Rein is excreted by the kidneys unchanged (20%) and as glucuronide (60%) and sulfate (20%).

Indications

Primary and secondary osteoarthritis.

Pharmacological effect

Pharmaceutical group:

A drug used for inflammatory and inflammatory-dystrophic diseases of the musculoskeletal system.

Pharmaceutical action:

Arthrodarin is an anti-inflammatory drug, an inhibitor of the synthesis and activity of interleukin-1 (IL-1). IL-1 plays an important role in the development of inflammation, degradation and subsequent destruction of cartilage in osteoarthritis.

In addition, diacerein inhibits the action of other cytokines that cause inflammation, including IL-6, TNF-α. Diacerein also slows down the formation of metalloproteases (collagenase, elastase), which are involved in the process of damage to cartilage tissue. With long-term use, diacerein stimulates the synthesis of proteoglycans and does not affect the synthesis of prostaglandins.

Pharmacokinetics:

Absorption and Metabolism

After taking the drug Arthrodarin orally, diacerein is quickly absorbed from the gastrointestinal tract and is completely deacetylated to rhein. Taking the drug simultaneously with food increases bioavailability by 25%. Cmax of rhein in plasma is reached after 144 minutes. With a single dose of 50 mg, Cmax reaches 3.15 mg/l. With repeated administration of the drug, Cmax of rheina increases due to cumulation.

Distribution and excretion

The binding of rhein to albumin reaches almost 100%. Rein penetrates the BBB and the placental barrier. T1/2 is 255 min. Rhine is excreted by the kidneys unchanged (20%) and in the form of glucuronide (60%) and sulfate (20%).

Special instructions

The duration of treatment, depending on the result achieved, can be long. In the period preceding the development of the therapeutic effect.

Arthrodarin can be taken simultaneously with analgesics and non-steroidal anti-inflammatory drugs.

Active ingredient

Diacerein

Composition

1 caps. contains diacerein 50 mg;

excipients:

lactose monohydrate,

croscarmellose sodium salt,

povidone K30,

colloidal silicon dioxide,

magnesium stearate, indigotine (E-132),

iron oxide yellow (E-172),

titanium oxide (E-171),

gelatin.

Contraindications

— pregnancy;
– lactation (breastfeeding);
– childhood and adolescence (up to 18 years);
– individual intolerance to the components of the drug Arthrodarin or hypersensitivity to anthraquinone drugs (for example, laxatives).
Prescribe with caution to patients with irritation of the lower intestines and chronic renal failure.

Side Effects

In case of hypersensitivity to the components of Arthrodarin, allergic reactions of varying degrees may occur.
During the initial period of taking the drug, symptoms from the digestive system may temporarily occur (in this case, the dosage can be reduced to 1 capsule per day):

– Diarrhea.
– Nausea and vomiting.
– Abdominal pain.

During treatment, intense coloration of urine from yellow to brown (depending on pH) may occur, which does not require dose reduction (cancellation) of the drug.

Interaction

Arthrodarin® should not be taken simultaneously with substances that affect the quality of intestinal contents and the rate of bowel movement (including large amounts of fiber).

Antacids reduce the absorption of the drug.

When used simultaneously with antibiotics or chemotherapy drugs that affect the intestinal microflora, an increase in the frequency of adverse reactions from the intestine is possible.

Overdose

Symptoms: diarrhea, weakness.

Treatment: symptomatic. The patient should be warned about the need to consult a doctor in case of overdose.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

TRB Pharma, Argentina