Antigrippin, honey-lemon 5 g 3 pcs.

Combination drug.

Paracetamol has analgesic and antipyretic effects; relieves headache and other types of pain, reduces fever.

Chlorphenamine is a blocker of histamine H1-receptors; it has anti-allergic effect; it relieves nasal breathing, sneezing, lacrimation, itching and red eyes.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, increases the body’s resistance.

Indications

Infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses.

Pharmacological effect

Combined drug.

Paracetamol has an analgesic and antipyretic effect; eliminates headaches and other types of pain, reduces fever.

Chlorphenamine is a blocker of histamine H1 receptors, has an antiallergic effect, facilitates breathing through the nose, reduces nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, and increases the body’s resistance.

Special instructions

If you are taking metoclopramide, domperidone or cholestyramine, you should also consult your doctor.

With long-term use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases; monitoring of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid can distort laboratory test results (quantitative determination of glucose and uric acid in blood plasma, bilirubin, liver transaminase activity, LDH).

To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process. In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.

One honey-lemon sachet contains 1.793 g of sugar, which corresponds to 0.15 XE.

One sachet of chamomile contains 2.058 g of sugar, which corresponds to 0.17 XE.

Active ingredient

Paracetamol, Chlorphenamine, [Ascorbic Acid]

Composition

1 pack

Paracetamol 500 mg
chlorphenamine maleate 10 mg
ascorbic acid 200 mg

Excipients: sodium bicarbonate, citric acid, sorbitol, povidone K30, sucrose, sodium cyclamate, aspartame, acesulfame potassium, lemon flavor.

Contraindications

Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug;
erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
severe renal and/or liver failure;
alcoholism;
angle-closure glaucoma;
phenylketonuria;
prostatic hyperplasia;
pregnancy;
breastfeeding period;
children under 15 years of age.
With caution: renal and/or liver failure, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis, old age.”

Side Effects

The drug is well tolerated in recommended doses.

In isolated cases there are:

from the central nervous system: headache, feeling of fatigue;

from the gastrointestinal tract: nausea, pain in the epigastric region;

from the endocrine system: hypoglycemia (up to the development of coma);

from the hematopoietic organs: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rarely – thrombocytopenia;

allergic reactions: skin rash, itching, urticaria, Quincke’s edema, anaphylactoid reactions (including anaphylactic shock), exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome);

Other: hypervitaminosis C, metabolic disorders, feeling of heat, dry mouth, accommodation paresis, urinary retention, drowsiness.

All side effects of the drug should be reported to your doctor.

Interaction

Ascorbic acid:

– increases the concentration of benzylpenicillin and tetracyclines in the blood;
– improves the absorption of iron preparations in the intestine (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine;
– increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood;
– increases the overall clearance of ethanol;
– when used simultaneously, reduces the chronotropic effect of isoprenaline;
– can both increase and decrease the effect of anticoagulant drugs;
– reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants;
– simultaneous use of barbiturates increases the excretion of ascorbic acid in the urine.

Chlorphenamine maleate:

Chlorphenamine maleate enhances the effect of hypnotics. Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) – increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids – increase the risk of developing glaucoma. Ethanol enhances the sedative effect of chlorphenamine maleate.

Paracetamol:

When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), the production of hydroxylated active metabolites increases, which makes it possible to develop severe intoxications with small overdoses.

While taking paracetamol, ethanol contributes to the development of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.

The simultaneous use of diflunisal and paracetamol increases the plasma concentration of the latter by 50%, increasing hepatotoxicity. Concomitant use of barbiturates reduces the effectiveness of paracetamol.
Paracetamol reduces the effectiveness of uricosuric drugs.”

Overdose

An overdose of the drug is due to the substances included in its composition. The clinical picture of an acute overdose of paracetamol develops within 6-14 hours after administration.

Symptoms of chronic overdose: appear 2-4 days after increasing the dose of the drug.

Symptoms of acute overdose: include gastrointestinal disorders (diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain), increased sweating.

Symptoms of chlorphenamine overdose: depression, seizures and coma may occur.

Treatment: symptomatic.

Short product description

“Complex drug for symptomatic treatment of ARVI.

When there is no time to get sick – AntiGrippin – triple power against 8 symptoms of ARVI and colds.

1) 3 active components act on 8 symptoms of ARVI and colds

2) Does not contain phenylephrine and caffeine

3) AntiGrippin in the form of effervescent tablets does not contain sugar “

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Shelf life

3 years.

Manufacturer

Natur Product Pharma Sp. z o.o., Poland