Antigrippin, 500 mg+10 mg+200 mg 30 pcs.

A combined drug.

Paracetamol – has analgesic and antipyretic effect, eliminates headache and other types of pain, reduces fever.

Ascorbic acid (vitamin C) – is involved in the regulation of redox processes and carbohydrate metabolism, increases the body’s resistance.

Chlorphenamine is a blocker of H1-histamine receptors – has anti-allergic effect, facilitates nasal breathing, reduces nasal congestion, sneezing, lacrimation, itching and red eyes.

Indications

Infectious inflammatory diseases (SARS, flu), accompanied by:

Composition

1 effervescent tablet contains:

Active substances:

Paracetamol 500 mg;

Chlorphenamine maleate 10 mg;
Ascorbic acid 200 mg.

Auxiliary substances:

sodium bicarbonate;

citric acid;

macrogol;

sodium lauryl sulfate;

Lime flavoring (Lime fruit flavoring additive).

How to take, the dosage

Adults and children over 15 years of age: Orally, 1 tablet 2-3 times a day. The interval between doses of the drug should be at least 4 hours.

The tablet should be dissolved completely in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution should be drunk immediately. It is better to take the drug between meals.

The maximum daily dose is 3 tablets.

The duration of use without consulting a doctor is not more than 5 days when prescribed as a pain reliever and 3 days as an antipyretic.

Particular Clinical Use

In patients with impaired hepatic or renal function and in elderly patients, the interval between doses of the drug must be at least 8 hours.

Interaction

Ethanol increases the sedative effect of antihistamines. Antidepressants, antiparkinsonian drugs, antipsychotics (phenothiazine derivatives) – increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids – increase the risk of glaucoma.

Concomitant use decreases the chronotropic effect of isoprenaline.

Decreases the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, the channel reabsorption of amphetamine and tricyclic antidepressants.

The inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which causes the possibility of severe intoxication in small overdoses. Ethanol promotes the development of acute pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects.

Concomitant use of the drug and diflunisal increases the plasma concentration of paracetamol by 50%, hepatotoxicity increases. Concomitant use of barbiturates reduces the effectiveness of paracetamol, increases excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

Special Instructions

Consult a physician when taking metoclopramide, domperidone, or colestiramine.

Paracetamol and ascorbic acid may distort laboratory tests (quantitative determination of plasma glucose and uric acid, bilirubin, activity of “hepatic” transaminases, LDH).

Long-term use at doses significantly higher than recommended increases the likelihood of liver and renal dysfunction; peripheral blood counts should be monitored.

To avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages and should not be taken by persons who are prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.

Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Contraindications

With caution:

Side effects

The drug is well tolerated in the recommended doses. In isolated cases occur:

CNS side: headache, feeling of fatigue.

Gastrointestinal disorders: nausea, pain in the epigastric region.

Endocrine system: hypoglycemia (up to coma).

Hematopoietic disorders: anemia, hemolytic anemia (especially in patients with glucose-6-phosphate dehydrogenase deficiency); very rarely – thrombocytopenia.

Allergic reactions: skin rash, pruritus, urticaria, Quincke’s edema.

Others: hypervitaminosis, metabolic disorders, fever, dry mouth, accommodation paresis, urinary retention, drowsiness.

All side effects of the drug should be reported to the physician.

Overdose

An overdose of the drug is caused by its constituent substances. The clinical picture of acute overdose with paracetamol develops within 6-14 hours after intake.

The symptoms of chronic overdose: appear 2-4 days after increasing the dose of the drug.

The symptoms of acute overdose: include GI disorders (diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain), increased sweating.

Symptoms in chlorphenamine overdose: depression, seizures and coma may occur.

Treatment: symptomatic.

Pregnancy use

It is contraindicated in pregnancy and lactation.

Administration in children

It is contraindicated in children under 15 years of age.

Children over 15 years – 1 tablet 2-3 times a day.