Antigrippin, 500 mg+10 mg+200 mg 10 pcs.

Combination drug.

Paracetamol has analgesic and antipyretic effects.

Chlorphenamine (blocker of histamine H1-receptors) has anti-allergic effect, reduces mucosal edema of the upper respiratory tract.

Ascorbic acid normalizes capillary permeability, has an antioxidant effect and helps increase the body’s resistance.

Indications

Infectious inflammatory diseases (SARS, flu), accompanied by:

Composition

1 effervescent tablet contains:

Active substances

Associates:

Sodium bicarbonate;

citric acid;

How to take, the dosage

Ingestion. Adults and children over 15 years old take 1 tablet 2-3 times a day. The tablet should be dissolved completely in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution should be drunk immediately.

It is better to take the drug between meals. The maximum daily dose is 3 tablets.

The interval between doses of the drug should be at least 4 hours. In patients with hepatic or renal dysfunction and in elderly patients the interval between doses of the drug should be at least 8 hours.

The duration of use without consulting a physician is not more than 5 days when prescribed as a pain reliever and 3 days as an antipyretic.

Interaction

Ethanol increases the sedative effect of antihistamines. Antidepressants, antiparkinsonian drugs, antipsychotics (phenothiazine derivatives) – increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids – increase the risk of glaucoma.

Concomitant use decreases the chronotropic effect of isoprenaline.

Decreases the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, the channel reabsorption of amphetamine and tricyclic antidepressants.

The inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which causes the possibility of severe intoxication in small overdoses. Ethanol promotes the development of acute pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) decrease the risk of hepatotoxic action. Concomitant use of the drug and diflunisal increases the plasma concentration of paracetamol by 50%, hepatotoxicity increases. Concomitant use of barbiturates reduces the effectiveness of paracetamol and increases ascorbic acid excretion with urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

Special Instructions

Physician should be consulted when taking metoclopramide, domperidone or colestiramine.

Paracetamol and ascorbic acid may distort laboratory tests (quantitative determination of plasma glucose and uric acid, bilirubin, activity of “liver” transaminases, LDH).

Long-term use at doses significantly higher than recommended increases the likelihood of liver and renal dysfunction; peripheral blood counts should be monitored.

To avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages and should not be taken by persons who are prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.

Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Contraindications

Side effects

The drug is well tolerated in the recommended doses. In isolated cases occur:

CNS side: headache, feeling of fatigue.

Gastrointestinal disorders: nausea, pain in the epigastric region.

Endocrine system: hypoglycemia (up to coma).

Hematopoietic disorders: anemia, hemolytic anemia (especially in patients with glucose-6-phosphate dehydrogenase deficiency); very rarely – thrombocytopenia.

Allergic reactions: skin rash, pruritus, urticaria, Quincke’s edema.

Others: hypervitaminosis, metabolic disorders, fever, dry mouth, accommodation paresis, urinary retention, drowsiness.

All side effects of the drug should be reported to the physician.

Overdose

An overdose of the drug is caused by its constituent substances. The clinical picture of acute overdose with paracetamol develops within 6-14 hours after intake.

The symptoms of chronic overdose: appear 2-4 days after increasing the dose of the drug.

The symptoms of acute overdose: include gastrointestinal disorders (diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain), increased sweating.

Chlorphenamine overdose symptoms: depression, seizures and coma may occur.

Treatment: symptomatic.

Pregnancy use

Administration in children

Children over 15 years of age – 1 tablet 2-3 times a day.