Antareit, 800 mg+400 mg 12 pcs

Combination drug, the action of which is caused by the properties of its constituent components. It has antacid, adsorptive, coating, diarrheal action.

Magaldrate

Magaldrate (aluminum magnesium hydroxide sulfate) neutralizes free hydrochloric acid in the stomach without causing secondary hypersecretion of gastric juice. Due to the increase in pH when taking it, the peptic activity of the gastric juice is reduced. It has adsorptive and coating effect due to which the impact of damaging factors on the gastric mucosa decreases; it binds bile acids.

Simethicone

Simethicone changes the surface tension of gas bubbles formed in the contents of the stomach and intestinal mucus and causes their destruction. The gases released may be absorbed by the cells of the intestinal wall or they may be expelled by peristalsis. Simethicone removes foam in a purely physical way, does not react chemically, and is pharmacologically inert.

Pharmacokinetics

Magaldrate

The absorption of aluminum and magnesium ions in the blood is low. With normal renal function, the concentration of aluminum and magnesium in the blood is not altered. In patients with chronic renal failure, the content of aluminum and magnesium in the blood may increase to toxic values as a result of impaired excretion.

Simethicone

Simethicone due to its pharmacological and chemical inertness after oral administration is not absorbed into the organs and tissues. After passing through the gastrointestinal tract (GIT) it is excreted unchanged by the intestine.

Indications

Symptoms associated with increased gastric acidity and reflux esophagitis: Heartburn, “sour taste” belching, stomach pain (appears irregularly), feeling of congestion or heaviness in epigastric area, flatulence, dyspepsia (including those caused by inappropriate diet, taking medications, abuse of alcohol, coffee, nicotine).

Active ingredient

Composition

1 chewable tablet in a dosage of 800 mg + 40 mg contains:

The active ingredients: magaldrate – 800.00 mg, simethicone (in terms of dimethyl polysiloxane) – 61.54 (40.00) mg.

Excipients: ethylcellulose – 36.00 mg, macrogoal-4000 – 140.00 mg, sorbitol – 513.18 mg, sucralose – 4.32 mg, aspartame – 5.00 mg, caramel flavoring – 12.96 mg, colloidal silicon dioxide – 9.00 mg, glyceryl dibegenate – 18.00 mg.

The weight of the tablet is 1600.00 mg.

How to take, the dosage

Ingestion. The tablets should be carefully chewed or kept in the mouth until they are completely absorbed.

Adults and adolescents over 12 years of age: Unless otherwise advised by the physician, take 1-2 tablets shortly after a meal. The medicine may be repeated after 2 hours, if necessary.

The maximum daily dose for 400 mg+20 mg tablets is 16 tablets; for 800 mg+40 mg tablets, 8 tablets.

Interaction

Antareit reduces and slows the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H2-histaminoblockers, beta-adrenoblockers, diflunisal, isoniazid, tetracycline antibiotics, quinolones (ciprofloxacin, norfloxacin, ofloxacin, enoxacin, grepofloxacin and others.), azithromycin, cefpodoxime, pivampicillin, rifampicin, indirect anticoagulants, barbiturates, fexofenadine, dipyridamole, zalcitabine, bile acids – chenodeoxycholic and ursodeoxycholic, penicillamine, drugs of iron and lithium, quinidine, lansoprazole, mexiletine, ketoconazole.

M-cholinoblockers, by slowing gastric emptying, increase and prolong the effects of the drug.

Special Instructions

In case of concomitant use of Antareit and other drugs, an interval of at least 1-2 hours should be observed. In case of prolonged use sufficient intake of phosphorus with food should be provided. In case of mild to moderate renal dysfunction, regular control of aluminum, calcium, phosphate in blood plasma is necessary. The drug contains sorbitol, which is contraindicated in congenital fructose intolerance.

Synopsis

Contraindications

Hypersensitivity to the components of the drug; severe renal failure; hypophosphatemia; fructose intolerance (due to the presence of sorbitol in the drug); children under 12 years of age.

With caution: with renal failure (increased plasma levels of magnesium and aluminum may increase with prolonged use); with Alzheimer’s disease; with low dietary phosphate content (risk of phosphate deficiency).

Side effects

Allergic reactions, nausea, vomiting, taste disorders, constipation, diarrhea.

In long-term use in high doses – hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminemia, encephalopathy, nephrocalcinosis, renal dysfunction. In patients with concomitant renal failure – feeling of thirst, decreased blood pressure, hyporeflexia.

Overdose

Symptoms: prolonged high doses may cause kidney stone formation, constipation, drowsiness, hypermagnesemia. There may also be signs of metabolic alkalosis: mood lability, numbness or pain in the muscles, nervousness and rapid fatigue, unpleasant taste sensations.

Treatment: measures must be taken to quickly eliminate the drug: flush the stomach, induce vomiting, take activated charcoal.

Pregnancy use

Controlled clinical studies investigating the use of Antareit in pregnant women have not been conducted, but no teratogenic effect or effect has been observed in preclinical studies. Due to insufficient clinical experience, use of the drug during pregnancy is possible only if the benefit to the mother outweighs the potential risk to the fetus.

Prescribing the drug in high doses and for a long time during pregnancy should be avoided.

There is no need to stop breastfeeding while taking Antareit.