Angiorus, 50 mg+450 mg 60 pcs

Pharmacodynamics. It has venotonic and angioprotective properties. The drug reduces venous distensibility and venous stasis, decreases capillary permeability and increases their resistance, improves microcirculation and lymph outflow.

Systematic administration reduces clinical symptoms of chronic venous insufficiency of the lower limbs of organic and functional nature.

Pharmacokinetics.

The main excretion of the drug is through the intestine. The kidneys excrete on average about 14 % of the drug intake. The half-life period of excretion is 11 hours.

The drug undergoes active metabolism, which is confirmed by the presence of phenolic acids in urine.

Indications

Active ingredient

Composition

Active ingredients: hesperidin – 50 mg, diosmin – 450 mg.

Excipients: hypromellose (oxymethylpropylcellulose) – 6.5 mg, lactose monohydrate (milk sugar) – 42 mg, talc – 22.8 mg, magnesium stearate – 7.6 mg, sodium carboxymethyl starch (sodium glycolate) – 22.8 mg, microcrystalline cellulose – 158.3 mg.

Shell composition: opadray II yellow – 22.8 mg.

The composition of opadray II yellow: macrogol-4000 (polyethylene glycol-4000) – 4.6056 mg, titanium dioxide – 1.6188 mg, talc – 3.3744 mg, polyvinyl alcohol – 9.1200 mg, iron oxide yellow dye – 4.0812 mg.

How to take, the dosage

Overly, with meals.

In case of veno-lymphatic insufficiency, 2 tablets per day (one or two doses): morning, afternoon and/or evening.

The duration of treatment can be several months (up to 12 months). In case of recurrence of symptoms, the course of treatment may be repeated upon the doctor’s recommendation.

In case of acute hemorrhoids, 6 tablets a day: 3 tablets in the morning and 3 tablets in the evening for 4 days, then 4 tablets a day: 2 tablets in the morning and 2 tablets in the evening for the next 3 days.

The recommended dose for chronic hemorrhoids is 2 tablets per day.

Interaction

There are no data on interactions with other medicines.

Special Instructions

Consultation with your doctor is recommended before you start taking ANGYRUS.

In case of exacerbation of hemorrhoids, the prescription of ANGYRUS does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section “Method of administration and dosage”. If symptoms persist after the recommended course of therapy, proctologic examination should be performed and the therapy used should be reviewed.

In the presence of venous circulatory disorders, the maximum effect of treatment is achieved by combining therapy with a healthy (balanced) lifestyle: it is advisable to avoid long periods of exposure to the sun, prolonged periods of standing on feet and it is also recommended to reduce excessive body weight. Walking and, in some cases, wearing special stockings to improve blood circulation.

Contact your physician immediately if your condition worsens or does not improve during treatment.

Influence on driving and operating ability

Contraindications

Hypersensitivity, period of breastfeeding.

Side effects

The frequency of adverse reactions is given according to the WHO classification: Very common (>1/10); common (>1/100, <1/10 ); infrequent (>1/1000, <1/100); rare (>1/10 000, <1/1000); very rare (<1/10 000, including individual reports); frequency unknown (frequency cannot be calculated from available data).

Central nervous system disorders:

Digestive system disorders:

Frequent unknown: abdominal pain.

Allergic reactions:

Frequency unknown: isolated swelling of the face, lips, eyelids. In exceptional cases, angioedema.

Pregnancy use

There have been no animal experiments showing teratogenic effects.

To date there have been no reports of adverse effects when using the drug in pregnant women.

Because of the lack of data concerning excretion of the drug into the breast milk, it is not recommended to take the drug during breastfeeding.

Reproductive toxicity studies have shown no effect on reproductive function in rats of either sex.

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