Angioflux, capsules 250 units, 50 pcs.

An anticoagulant agent, heparinoid. It has antiaggregant, antithrombotic, angioprotective, hypolipidemic and fibrinolytic effect.

The active ingredient is an extract from the mucous membrane of small intestine of animals, it is a natural mixture of fast-moving heparin-like fraction (80%) and dermatan-sulfate (20%).

Suppresses activated factor X, increases the synthesis and secretion of prostacyclin (prostaglandin PgI2), reduces the concentration of plasma fibrinogen. Increases the concentration of the activator of tissue profibrinolysin (plasminogen) in blood and decreases the blood concentration of its inhibitor.

The mechanism of angioprotective action is associated with restoration of structural and functional integrity of vascular endothelial cells, as well as the normal density of the negative electric charge of pores of the basal membrane of vessels. Normalizes rheological properties of blood by reducing TG and decreasing blood viscosity.

The efficacy of use in diabetic nephropathy is determined by reduction of basal membrane thickness and decrease of matrix production due to decrease of mesangium cell proliferation.

Indications

Active ingredient

Composition

1 capsule contains:

Active ingredient:

sulodexide 250 LE (lipoproteinlipase units).

Auxiliary substances:

glyceryl caprylocaprate (Migliol 812),

sodium lauryl sulfate,

colloidal silicon dioxide.

Capsule shell composition:

gelatin, glycerol, sodium ethyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, iron oxide red dye (E 172).

How to take, the dosage

Intravenously.

Individual, depending on the clinical situation.

Interaction

The use of anticoagulants (direct and indirect) and antiaggregants at the same time is not recommended.

Special Instructions

When using sulodexide, the state of the clotting system (coagulogram) should be regularly monitored.

The simultaneous use of anticoagulants (direct and indirect) and antiaggregants is not recommended.

Contraindications

Side effects

Digestive system: nausea, vomiting, epigastric pain.

Others: skin rash.

Pregnancy use

The drug is contraindicated in pregnancy and during lactation (breast-feeding).

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