Andipal, tablets 20 pcs

Pharmacotherapeutic group: analgesic combination medicine (analgesic non-narcotic + antispasmodic + barbiturate).

ATX code: N02BB72

Pharmacological properties

Pharmacodynamics

p>Combination drug, has vasodilatory, analgesic, antispasmodic and sedative effects.

Andipal, as an antispasmodic agent, is used for spasms of peripheral blood vessels and cerebral vessels.

Lowering total peripheral resistance, acting on the arterioles, the drug reduces blood pressure and improves collateral circulation.

The combination of myotropic antispasmodics (bendazole and papaverine) with sodium metamizole increases the analgesic effect of the latter in headache and migraine. The presence of phenobarbital in the drug contributes to the sedative effect and enhances the action of the other components.

Pharmacokinetics

Sodium metamizole:is well and quickly absorbed into the gastrointestinal tract. In the intestinal wall it is hydrolyzed to form the active metabolite, unchanged sodium metamizole is absent in blood (only after intravenous administration a small concentration is found in plasma). Binding of active metabolite with plasma proteins is 50-60%. It is metabolized in the liver and excreted by the kidneys. In therapeutic doses penetrates into breast milk.

Papaverine:absorption depends on the dosage form. The bioavailability on average is 54%. Binding with plasma proteins – 90%. Well distributed, penetrates through histohematic barriers. It is metabolized in liver. Half-life (T_1/2) is 0.5-2 hours (may be prolonged up to 24 hours). It is excreted by the kidneys as metabolites. Completely eliminated from the blood by hemodialysis.

Phenobarbital:when ingested, phenobarbital is completely but relatively slowly absorbed. The maximum concentration in the blood is observed 1-2 h after ingestion. About 50% is bound to plasma proteins. The drug is evenly distributed in different organs and tissues; lower concentrations are found in brain tissues. The half-life in adults is 2-4 days. It is excreted from the body slowly, which creates conditions for cumulation. It is metabolized by liver microsomal enzymes. It is excreted by kidneys as inactive metabolites and 25-50% – unchanged.

Indications

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How to take, the dosage

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