Amlorus, tablets 5 mg 30 pcs

Amlorus is a dihydropyridine derivative, a II generation “slow” calcium channel blocker with antianginal and hypotensive effects. Binding to dihydropyridine receptors, it blocks calcium channels, reduces transmembrane transfer of calcium ions into the cell (more in vascular smooth muscle cells than in cardiomyocytes).

Indications

Arterial hypertension (monotherapy or in combination with other antihypertensive drugs: diuretics, beta-blockers, ACE inhibitors (angiotensin-converting enzyme).

Pharmacological effect

Amlorus, a dihydropyridine derivative, is a blocker of “slow” calcium channels of the second generation, has an antianginal and hypotensive effect. By binding to dihydropyridine receptors, it blocks calcium channels, reduces the transmembrane transition of calcium ions into the cell (more into vascular smooth muscle cells than into cardiomyocytes).

Special instructions

During the treatment period, it is necessary to monitor body weight and sodium intake, and prescribe an appropriate diet.
It is necessary to maintain dental hygiene and frequent visits to the dentist (to prevent soreness, bleeding and gum hyperplasia).

Active ingredient

Amlodipine

Composition

One tablet contains amlodipine besilate (in terms of amlodipine) – 5 mg;

Contraindications

hypersensitivity to amlodipine and other dihydropyridine derivatives;
severe arterial hypotension;
collapse, cardiogenic shock;
unstable angina (with the exception of Prinzmetal’s angina);
pregnancy and lactation;
age under 18 years (efficacy and safety have not been established).

With caution: impaired liver function, sick sinus syndrome (severe bradycardia, tachycardia), chronic cardiac failure in the decompensation stage, mild or moderate arterial hypotension, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and within 1 month after), diabetes mellitus, lipid profile disorders, old age.

Side Effects

From the cardiovascular system: palpitations, shortness of breath, marked decrease in blood pressure, fainting, vasculitis, edema (swelling of the ankles and feet), flushing of the face, rarely – rhythm disturbances (bradycardia, ventricular tachycardia, atrial flutter), chest pain, orthostatic hypotension, very rarely – development or worsening of heart failure, extrasystole, migraine.

Interaction

Inhibitors of microsomal oxidation increase the concentration of amlodipine in the blood plasma, increasing the risk of side effects, and inducers of microsomal liver enzymes reduce it.

Overdose

Symptoms: marked decrease in blood pressure, tachycardia, excessive peripheral vasodilation.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Sintez, Russia