Amixin, 60 mg 10 pcs
€19.20 €16.00
ATX code: J05AX
Pharmacological properties
Pharmacodynamics.
Low molecular synthetic inducer of interferon which stimulates formation of all types of interferons in the body (alpha, beta, gamma and lambda).
The main producers of interferon in response to tiloron administration are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration, the maximum production of interferon is determined in the gut-liver-blood sequence after 4-24 hours. Amixin ® has immunomodulatory and antiviral effect.
According to the data of experimental studies after a single oral administration of Amixin® in dose equivalent to maximum daily dose for human the maximum concentration in lung tissue of interferon lambda is determined after 24 hours, of interferon alpha – after 48 hours.
The induction of interferon lambda in the lung tissue increases antiviral protection of the respiratory tract in influenza and other respiratory viral infections.
In human leukocytes it induces synthesis of interferon. It stimulates bone marrow stem cells, depending on the dose it increases antibody formation, decreases the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers.
It is effective against various viral infections including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with inhibition of translation of virus-specific proteins in infected cells, resulting in suppression of virus reproduction.
Pharmacokinetics.
After oral administration it is quickly absorbed from the gastrointestinal tract. Bioavailability is 60%. About 80% of the drug is bound to plasma proteins. The drug is eliminated practically unchanged in intestine (70%) and kidney (9%). The elimination half-life (T1/2) is 48 hours. The drug is not biotransformed and does not accumulate in the body.
Indications
As part of complex therapy:
In children from 7 to 18 years:
– treatment of flu and other acute respiratory viral infections (ARI).
In adults:
– treatment of influenza and other acute respiratory viral infections;
– treatment of herpetic infection.
Prevention of influenza and other acute respiratory infections in adults.
Active ingredient
Composition
Tiloron – 60.0 mg or 125.0 mg.
The excipients:
Core: Potato starch – 25,500 mg or 46,000 mg, microcrystalline cellulose – 60,000 mg or 120,000 mg, povidone (povidone K30) – 1,500 mg or 3,000 mg, calcium stearate – 1,500 mg or 3,000 mg, croscarmellose (croscarmellose sodium) – 1,500 mg or 3,000 mg;
coating: Hypromellose (hydroxypropyl methylcellulose) – 3.4050 mg or 6.8100 mg, titanium dioxide – 1.7815 mg or 3.5630 mg, macrogol (polyethylene glycol-4000) – 0.4565 mg or 0.9130 mg, polysorbate-80 (tween-80) – 0.0570 mg or 0.1140 mg, quinoline yellow dye (E 104) – 0.1235 mg or 0.2470 mg, sunset yellow dye (E 110) – 0.1765 mg or 0.3530 mg.
How to take, the dosage
Amixin® is taken orally, after meals.
For children from 7 to 18 years:
In uncomplicated forms of influenza and other acute respiratory infections – 60 mg once a day on the 1st, 2nd and 4th day from the start of treatment. The course dose is 180 mg (3 pills).
For adults:
For treatment of influenza and other acute respiratory viral infections – 125 mg daily for the first 2 days of treatment, then 125 mg every 48 hours. For a course of 750 mg (6 tablets).
For the prevention of flu and other acute respiratory infections – 125 mg once a week for 6 weeks. For a course – 750 mg (6 tablets).
For the treatment of herpetic infection – the first two days in 125 mg, then in 48 hours in 125 mg. The course dose is 1.25-2.5 g (10-20 tablets).
When treating influenza and other acute respiratory infections, if symptoms persist for more than 4 days, consult a physician.
Interaction
Compatible with antibiotics and drugs of traditional treatment of viral and bacterial diseases. No clinically significant interaction of Amixin® with antibiotics and drugs of traditional treatment of viral and bacterial diseases was found.
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Special Instructions
The drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.
Contraindications
Side effects
Allergic reactions, dyspeptic phenomena, short-term chills are possible. If any of the side effects mentioned in the instructions are aggravated, or if you notice any other side effects not specified in the instructions, inform your doctor.
Overdose
To date, there have been no known cases of Amixin overdose.
Pregnancy use
The use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be stopped.
Similarities
Weight | 0.024 kg |
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Shelf life | 3 years |
Conditions of storage | In a dry, light-protected place at a temperature not exceeding 30 °C |
Manufacturer | Pharmstandard-Leksredstva, Russia |
Medication form | pills |
Brand | Pharmstandard-Leksredstva |
Other forms…
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