Amixin, 125 mg 6 pcs

Pharmgroup:

antiviral immunostimulatory agent – inducer of interferon formation.

Pharmacological action:

Amixin is a low molecular weight synthetic interferon inducer that stimulates formation of interferon alpha, beta and gamma in the body. The main producers of interferon in response to tiloron administration are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration the maximum production of interferon is determined in the sequence intestine – liver – blood in 4-24 hours.

Amixin® has immunomodulatory and antiviral effect.

In human leukocytes it induces synthesis of interferon. It stimulates bone marrow stem cells, and depending on the dose increases antibody formation, decreases the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers.

It is effective against various viral infections including flu viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with inhibition of translation of virus-specific proteins in infected cells, resulting in suppression of virus reproduction.

Pharmacokinetics:

After oral administration it is quickly absorbed from the gastrointestinal tract. Bioavailability is 60%. About 80% of the drug is bound to plasma proteins. The drug is excreted practically unchanged in intestine (70%) and kidney (9%). The elimination half-life (T1/2) is 48 hours. The drug is not biotransformed and does not accumulate in the body.

Indications

In adults, treatment and prevention of flu, other ARI, treatment of viral hepatitis, A, B and C; treatment of herpes, B and C.br> treatment of herpetic and cytomegalovirus infection;

In the complex therapy of infectious allergic and viral encephalomyelitis (multiple sclerosis, leukoencephalitis, uveoencephalitis, etc.).),

In the complex therapy of urogenital and respiratory chlamydia, in the complex therapy of pulmonary tuberculosis;

In children over 7 years old – for treatment of flu and other ARI.

Active ingredient

Composition

1 tablet contains Tiloron 125 mg,

excipients:

magnesium carbonate basic,

polyvinylpyrrolidone,

How to take, the dosage

The drug is taken orally after meals.

Nonspecific prophylaxis of viral hepatitis A
In adults for non-specific prophylaxis of viral hepatitis A the drug is prescribed in dose of 125 mg once a week for 6 weeks. The course dose is 750 mg (6 tablets).

Treatment of viral hepatitis A
In treatment of viral hepatitis A the first day dose of the preparation is 125 mg twice a day, then it is changed for 125 mg every 48 hours. The course of treatment is 1.25 g (10 tablets).

Treatment of acute hepatitis B
In treatment of acute hepatitis B in initial phase of therapy on the first and second day the drug dose is 125 mg daily, and then 125 mg after 48 hours. The course of treatment is 2 g (16 tablets).

In prolonged course of hepatitis B
In prolonged course of hepatitis B the dose of the preparation in the first day is 125 mg 2 times per day and then 125 mg after 48 hours. The course dose is 2.5 g (20 tablets).

Cronic hepatitis B
In chronic hepatitis B in initial phase of treatment the total dose is 2.5 g (20 tablets). During the first 2 days the daily dose is 250 mg, then it is transferred to 125 mg every 48 hours. In treatment continuation phase the total dose is from 1.25 g (10 tablets) to 2.5 g (20 tablets), while the drug is administered in dose of 125 mg per week. The course dose of Amixin varies from 3.75 to 5 g; therapy duration is 3.5-6 months, depending on the results of biochemical, immunological and morphological tests, reflecting the degree of activity of the process.

In acute hepatitis C
In acute hepatitis C on the first and second day of treatment Amixin is prescribed in a dose of 125 mg/day, then 125 mg after 48 hours. The course dose is 2.5 g (20 tablets).

Cronic hepatitis C
In chronic hepatitis C in the initial phase of treatment the total dose is 2.5 g (20 tablets). During the first 2 days the preparation is taken in dose 250 mg per day, then 125 mg every 48 hours. In treatment continuation phase the total dose is 2.5 g (20 tablets), while the drug is administered in a dose of 125 mg per week. Course dose of Amixin is 5 g (40 tablets), duration of treatment is 6 months, depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

In combination therapy of neuroviral infections

In combination therapy of neuroviral infections it is 125-150 mg/day in the first two days of therapy, then 125 mg every 48 hours. The dose is determined individually; duration of therapy is 3-4 weeks.

Treatment of influenza and other acute respiratory infections
For treatment of influenza and other acute respiratory viral infections during the first two days of treatment Amixin is administered in dose of 125 mg/day, then 125 mg after 48 hours. The course dose is 0.75 g (6 tablets).

Prevention of influenza and acute respiratory infections For prevention of influenza and acute respiratory infections Amixin is prescribed in a dose of 125 mg once a week for 6 weeks. The course dose is 750 mg (6 tablets).

The treatment of herpetic, cytomegalovirus infection.

To treat herpetic, cytomegalovirus infection, the dose of the drug in the first 2 days is 125 mg, then 125 mg every 48 hours. The course dose is 1.25-2.5 g (10-20 tablets).

Urogenital and respiratory chlamydia
In urogenital and respiratory chlamydia, Amixin is prescribed in a dose of 125 mg/day for the first 2 days, then 125 mg every 48 hours. The course dose is 1.25 g (10 tablets).

In complex therapy of tuberculosis
In complex therapy of pulmonary tuberculosis the drug is prescribed in dose of 250 mg/day in first 2 days and then in dose of 125 mg in 48 hours. The course dose is 2.5 g (20 tablets).

In children over 7 years old in uncomplicated forms of influenza and other ARIs

In children over 7 years old in uncomplicated forms of influenza or other ARIs the drug is prescribed in dose of 60 mg (1 tablet) 1 time per day after meals on days 1, 2 and 4 from the start of treatment. The course dose is 0.18 g (3 tablets).

In case of development of complications of flu and other acute respiratory viral infections.
In case of complications of flu and other acute respiratory viral infections the preparation is taken by 60 mg 1 time per day on the 1st, 2nd, 4th and 6th days after the treatment start. The course dose is 0.24 g (4 tablets).

Interaction

Amixin is compatible with antibiotics and traditional treatments for viral and bacterial infections.

Contraindications

Side effects

Digestive system: Symptoms of dyspepsia may occur.

Other: Possible short-term chills. Allergic reactions.

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