Amiodarone, tablets 200 mg 30 pcs

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Caution should be exercised when prescribing the drug in patients with heart failure, liver disease, hypokalemia, porphyria, elderly patients.

Before treatment and every 6 months during therapy, it is recommended to check thyroid function, “hepatic” transaminase activity and to perform radiological examination of the lungs and consult an ophthalmologist. Control ECGs should be taken every 3 months.

Please note that Amiodarone may distort the results of determining the concentration of thyroid hormones (triiodothyronine, thyroxine, thyrotropic hormone).

If the heart rate is below 55 bpm, the drug should be temporarily stopped.

Amiodarone use may cause ECG changes: prolongation of QT interval with possible occurrence of U wave. If atrioventricular block of II and III degree, sinoatrial block, as well as Gis bundle branch block occur, treatment with Amiodarone should be stopped immediately.

Cancellation may lead to recurrence of cardiac rhythm disturbances. After drug withdrawal, pharmacodynamic effects persist for 10-30 days. Before surgical interventions as well as oxygen therapy it is necessary to warn a physician about use of Amiodarone, as there have been rare cases of acute respiratory distress syndrome in adult patients in the postoperative period.

In order to avoid photosensitization, patients should avoid Sun exposure. Deposition of lipofuscin in the corneal epithelium resolves on its own when the dose is reduced or Amiodarone is withdrawn. Skin pigmentation decreases after discontinuation of the drug and gradually (within 1-4 years) disappears completely. Spontaneous normalization of thyroid function is usually observed after discontinuation of treatment.

Information on possible effect on the ability to drive vehicles, machinery

When using the drug, one should refrain from driving and engaging in potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Synopsis

Contraindications

Hypersensitivity to any of the drug components or iodine; sinus node weakness syndrome (sinus bradycardia and sinoatrial block in the absence of a pacemaker (risk of sinus node arrest); atrioventricular block of TI-III degree, two- and three-beam block (in the absence of a pacemaker); hypothyroidism, hyperthyroidism; severe arterial hypotension; lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome; hypokalemia, hypomagnesemia; interstitial lung disease; pregnancy, breastfeeding; concomitant use of monoamine oxidase inhibitors, QT interval prolongation drugs, congenital or acquired QT interval prolongation; age

Side effects

Frequency: very common (10% or more), common (1% or more; less than 10%), infrequent (0.1% or more; less than 1%), rare (0.01% or more; less than 0.1%), very rare (less than 0.01%, including individual cases), frequency unknown (no data available to determine frequency).

Cardiovascular system disorders: Frequent – moderate bradycardia (dose-dependent); infrequent – sinoatrial and atrioventricular block of various degrees, proarrhythmogenic effect; very rare – severe bradycardia, sinus node arrest (in patients with sinus node dysfunction and elderly patients); frequency unknown – ventricular pirouette tachycardia, progression of chronic heart failure symptoms (with long-term use).

Digestive system disorders: very frequently – nausea, vomiting, decreased appetite, dulling or loss of taste, metallic taste in the mouth, sensation of heaviness in epigastrium, isolated increase of “liver” transaminases activity; frequently – acute toxic hepatitis with increased “liver” transaminases activity and/or jaundice, including development of liver failure; very rarely – chronic liver failure.

Respiratory system: often – interstitial or alveolar pneumonitis, obliterating bronchiolitis with pneumonia, pleurisy, pulmonary fibrosis; very rare – bronchospasm in patients with severe respiratory failure (especially in patients with bronchial asthma), acute respiratory syndrome; frequency is unknown – pulmonary bleeding.

Overlooking organ: very common – micro deposition in the corneal epithelium consisting of complex lipids, including lipofuscin (complaints of color halo or blurred contours of objects in bright light); very rare – optic neuritis/ optic neuropathy.

Metabolism disorders: often – hypothyroidism, hyperthyroidism; very rarely – syndrome of abnormal secretion of antidiuretic hormone.Skin disorders: very often – photosensitization; often – grayish or bluish pigmentation of the skin (with long-term use), which disappears after discontinuation of the drug; very rarely – erythema (with simultaneous radiation therapy), skin rash, exfoliative dermatitis (no relation with taking the drug), alopecia; frequency unknown – urticaria.

Nervous system disorders: frequently – tremor and other extrapyramidal disorders, sleep disturbances; infrequently – peripheral neuropathy and/or myopathy; very rarely – cerebellar ataxia, benign intracranial hypertension, headache.

Others: frequency unknown – angioneurotic edema, formation of granulomas, including bone marrow granulomas; very rare – vasculitis, epididymitis, impotence (relationship with taking the drug is not established), thrombocytopenia, hemolytic and aplastic anemia.

If you have any side effects, you should stop taking the medicine and see your doctor.
If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Pregnancy use

Similarities