Ambrohexal, tablets 30 mg 20 pcs

Ambrohexal is a medicinal product with mucolytic, secretolytic and expectorant action, and the active ingredient of the drug is ambroxol.

The mechanism of action of this drug is associated with reduction of sputum viscosity as a result of depolymerization of sputum mucopolysaccharides, which consists in breaking disulfide bonds in molecules, increasing release of active hydrolyzing enzymes from Clark cells.

Ambrohexal also increases the activity of the cilia of the bronchial epithelium, and normalizes the ratio of all components of sputum and in this regard stimulates its mucociliary transport. This facilitates expectoration of sputum from the respiratory tract and stimulates secretion and blockage of surfactant breakdown.

Ambrohexal is rapidly absorbed from the gastrointestinal tract with high absorption capacity, and its optimal plasma concentration is reached within two hours after taking the drug: tablets, syrup, sustained release capsules and inhalation solution.

The action of the drug starts after 30 minutes after taking the syrup or tablets and depends on the speed of absorption of the drug in the stomach and intestines. The drug is metabolized in the liver, where it is converted to dobromanthranilic acid and glucuronic conjugates and excreted by the kidneys.

Indications

Acute, bronchitis with sputum retention, pneumoconiosis, bronchial asthma, pulmonary tuberculosis and cystic fibrosis, bronchiectatic disease, acute pneumonia, pleurisy, lung emphysema, acute, lingering and chronic sinusitis, chronic rhinitis.

Active ingredient

How to take, the dosage

Overly, after meals with enough fluids.

Adults and children over 12 years of age – 1 tablet (30 mg ambroxol) 3 times a day for the first 2-3 days, then the drug dose should be reduced to 1 tablet 2 times a day.

Children aged 6 to 12 years – 1/2 tablet (15 mg ambroxol) 2-3 times a day.

The duration of therapy depends on the severity of the disease and is determined by the attending physician. Without a doctor’s recommendation, the drug Ambrohexal® should not be taken longer than 4-5 days.

The mucolytic effect is increased with additional fluid intake. Therefore, it is necessary to consume enough fluids (juices, tea, water) during the treatment.

Interaction

Concomitant use with anti-cough drugs leads to difficulty of expectoration of sputum against the background of suppression of the cough reflex. It increases penetration into the bronchial secretion of amoxicillin, cefuroxime, erythromycin and doxycycline.

Special Instructions

Ambroxol should be used with caution in patients with impaired cough reflex or impaired mucociliary transport because of the possibility of sputum accumulation.

Patients taking ambroxol should not be advised to do breathing exercises; aspiration of diluted sputum should be performed in severely ill patients.

In patients with bronchial asthma, ambroxol may increase coughing.

Ambroxol should not be taken immediately before going to bed.

Ambroxol should not be taken at the same time as an anti-cough medication that may inhibit the cough reflex, such as codeine, because it may make it harder to remove liquefied sputum from the bronchial tree.

Hint for diabetic patients: 1 tablet contains less than 0.01 IU.

Contraindications

With caution: patients with renal and hepatic impairment.

Side effects

Digestive system disorders: nausea, vomiting, gastralgia, diarrhea, constipation, dry mouth.

Allergic reactions: skin rash, urticaria, angioedema, bronchospasm attack, fever with chills; anaphylactic shock; weakness, headache, rhinorrhea, increased salivation, dry airways, urinary disorders (dysuria).

Overdose

Symptoms: nausea, vomiting, gastralgia. There are reports of the occurrence of transient restlessness and diarrhea. In severe overdose there may be a drop in blood pressure.

Treatment: induction of vomiting, gastric lavage during the first 1-2 hours after taking the drug, prescription of fat-containing products.

Pregnancy use

Similarities