Almagel, suspension 170 ml

Pharmacotherapeutic group

Antacidal agent

ATX code: A02AX

Pharmacological action

Pharmacodynamics

Almagel® is a drug which is a balanced combination of algeldrate (aluminum hydroxide) and magnesium hydroxide. It neutralizes free hydrochloric acid in the stomach, reduces the activity of pepsin, which leads to a decrease in the digestive activity of gastric juice.

It has an enveloping, adsorptive effect. It protects the mucous membrane of the stomach by stimulating the synthesis of prostaglandins (cytoprotective effect). This protects the mucous membrane from inflammatory and erosive-hemorrhagic lesions due to irritating and ulcerogenic agents such as ethyl alcohol and nonsteroidal anti-inflammatory drugs (e.g., indomethacin, diclofenac, aspirin, acetylsalicylic acid, corticosteroid drugs). The therapeutic effect after taking the drug comes in 3-5 minutes.

The duration of action depends on the rate of gastric emptying. When taken on an empty stomach, the action lasts up to 60 minutes. When taken one hour after a meal the antacid action may last up to 3 hours. Does not cause secondary hypersecretion of gastric juice.

Pharmacokinetics

Algeldrate

Intake – small amounts of the drug are resorbed, which almost does not change the concentration of aluminum salts in the blood.

Distribution – no.

Metabolism – no.

Exhaustion – excreted through the intestine.

Magnesium hydroxide

Intake – Magnesium ions are resorbed in about 10% of the dose taken and do not change the concentration of magnesium ions in the blood.

Distribution – usually locally.

Metabolism – none. Excretion – excreted through the intestine.

Indications

Active ingredient

Composition

5 ml (one scoop) of the suspension contains:

The active ingredients:

Aluminum hydroxide gel -2.18 g

in terms of Al2O3 -218 mg

Magnesium hydroxide infusion – 350 mg

in terms of MgO – 75 mg

Excipients:

Hydrogen peroxide solution 30% – 0.41 mg,

sorbitol – 801.15 mg,

Guetellose – 10.90 mg,

methylparahydroxybenzoate – 10.90 mg,

propylparahydroxybenzoate – 1.363 mg,

Butyl parahydroxybenzoate – 1.363 mg,

sodium saccharinate dihydrate – 0.818 mg,

propylene glycol – 327.00 mg,

How to take, the dosage

Interaction

It may absorb some drugs, thus reducing their absorption, so if other drugs are taken at the same time, they should be taken 1-2 hours before or after taking Almagel.

Almagel reduces the acidity of gastric juice, and this may affect the effect of a large number of drugs when taken simultaneously.

Almagel reduces the effect of histamine H2-receptor blockers (cimetidine, ranitidine, famotidine), cardiac glycosides, iron salts, lithium drugs, quinidine, mexiletine, phenothiazine drugs, tetracycline antibiotics, ciprofloxacin, isoniazid and ketoconazole.

In concomitant administration of enteric drugs, elevated pH of gastric juice may lead to accelerated yus membrane disruption and cause irritation of the stomach and duodenum. Almagel can affect the results of some laboratory and functional studies and tests: it reduces the level of gastric secretion when determining its acidity; it changes the results of tests using technetium (TS??), such as bone scintigraphy and some tests for esophageal research, increases serum phosphorus levels, serum and urine pH values.

Special Instructions

The drug is not recommended in patients with severe constipation; with gastric pain of unclear origin and suspected acute appendicitis; with ulcerative colitis, diverticulosis, colostomy or ileostomy; with chronic diarrhea; acute hemorrhoids; with changes in the acid-base balance in the body and with metabolic alkalosis; In patients with liver cirrhosis; severe heart failure; toxemia during pregnancy; impaired renal function (creatinine clearance).

When taking the preparation for a long time (more than 20 days) it is necessary to have regular medical control of serum magnesium level during therapy of patients with renal insufficiency. The drug does not contain sugar, which allows patients with diabetes to take it. The drug contains sorbitol, which is contraindicated in cases of congenital fructose intolerance.

The effect of the drug on the ability to drive vehicles and other mechanisms:

Almagel has no effect on the ability to drive and operate machinery. When taken in the recommended daily dose, the ethyl alcohol in the drug does not affect the ability to drive and operate machinery.

Synopsis

Contraindications

Side effects

The adverse reactions are classified according to the World Health Organization (WHO) Classification: very common (≥1/10); common (≥1/100, < 1/10); infrequent (≥1/1000, < 1/100); rare (≥1/10000, < 1/1000); very rare (< 1/10000); frequency unknown (cannot be determined based on available data).

Disorders of the immune system: frequently, allergic reactions.

Disorders of the metabolism and nutrition: very rarely – hypermagnesemia1 (with associated arterial hypotension); frequency unknown – hypophosphatemia, hypercalciuria.

Muscular and connective tissue disorders: frequency unknown – osteomalacia.

Gastrointestinal tract disorders:rarely – nausea, vomiting, stomach cramp, change in taste; frequency unknown – abdominal pain1; constipation (passes after dose reduction).

Long-term use of the drug in patients with renal failure and patients on hemodialysis may cause changes in mood and mental alertness.

In prolonged use with high doses of the drug and phosphorus deficiency in food, osteomalacia may occur.

1 Observed with long-term use of magnesium hydroxide in patients with renal insufficiency.

Overdose

Symptoms:In a single dose above the recommended dose, there are usually no other signs of overdose other than constipation, flatulence, and a metallic taste in the mouth.

In prolonged high doses, kidney stone formation, severe constipation, mild drowsiness, and hypermagnesemia may occur. There may also be signs of metabolic alkalosis: changes in mood or mental alertness, numbness or pain in muscles, irritability and rapid fatigue, slowed breathing, unpleasant taste sensations.

Emergency measures:In these cases, measures should be taken immediately to quickly eliminate the drug from the body – gastric lavage, inducing vomiting, taking activated charcoal.

In case of overdose, symptomatic therapy is required.

Pregnancy use

Similarities