Allochol, 50 pcs.

Pharmacodynamics

Allochol refers to drugs that enhance bile formation. The mechanism of action is due to the reflexes of the intestinal mucosa, as well as the effect of Allochol on the secretory function of the liver. Allochol increases the amount of bile secreted, enhances secretory and motor functions of the gastrointestinal tract, reduces the processes of putrefaction and fermentation in the intestine. Allochol may serve as substitution therapy in endogenous bile acid deficiency.

Pharmacokinetics

Allochol is well absorbed in the gastrointestinal tract. Cholic and chenodeoxycholic acids contained in Allochol undergo 7α-dehydroxylation in the intestine. Henodeoxycholic acid, in addition, undergoes metabolism in the liver: it conjugates with amino acids, is secreted into bile, from where it is excreted again into the intestine, then partially reabsorbed; the rest is excreted with the feces.

Indications

Used for chronic hepatitis, cholangitis, cholecystitis and habitual constipation associated with intestinal atony.

Pharmacological effect

Pharmacodynamics

Allochol refers to drugs that enhance the formation of bile. The mechanism of action is due to reflexes of the intestinal mucosa, as well as the influence of Allochol on the secretory function of the liver. Allochol increases the amount of secreted bile, enhances the secretory and motor functions of the gastrointestinal tract, reduces the processes of putrefaction and fermentation in the intestines. Allochol can serve as a replacement therapy for endogenous bile acid deficiency.

Pharmacokinetics

Allochol is well absorbed from the gastrointestinal tract. Cholic and chenodeoxycholic acids contained in Allochol undergo 7α-dehydroxylation in the intestine. Chenodeoxycholic acid, in addition, undergoes metabolism in the liver: it is conjugated with amino acids, secreted into bile, from where it is again released into the intestine, then partially reabsorbed; the rest is excreted in feces.

Special instructions

The course of treatment with Allochol can be repeated 2-3 times with a break of 3 months.

Active ingredient

Activated carbon, Bile, Stinging nettle leaves, Garlic bulb

Composition

1 film-coated tablet contains:

active ingredients:

condensed bile in terms of dry matter or dry bile – 80 mg;

dried garlic – 40 mg;

nettle leaves – 5 mg;

activated carbon – 25 mg.

Contraindications

individual intolerance,
acute hepatitis,
acute and subacute liver dystrophies,
obstructive jaundice,
children up to 7 years of age (for this dosage form).

Side Effects

When using the drug, diarrhea may occur in some patients; allergic reactions. In these cases, the drug is discontinued.

Interaction

Preparations containing aluminum hydroxide, cholestyramine, cholestipol reduce absorption (and reduce the effect) – simultaneous use is not advisable.

Overdose

Possible diarrhea, nausea, heartburn, itching, increased levels of transaminases in the blood.

Storage conditions

Store in a dry place, protected from light, at a temperature from 15 to 25C

Shelf life

4 years

Manufacturer

Pharmstandard-Tomskkhimpharm, Russia