Allochol, 50 pcs.

Pharmacodynamics

Allochol refers to drugs that enhance bile formation. The mechanism of action is due to the reflexes of the intestinal mucosa, as well as the effect of Allochol on the secretory function of the liver. Allochol increases the amount of bile secreted, enhances secretory and motor functions of the gastrointestinal tract, reduces the processes of putrefaction and fermentation in the intestine. Allochol may serve as substitution therapy in endogenous bile acid deficiency.

Pharmacokinetics

Allochol is well absorbed in the gastrointestinal tract. Cholic and chenodeoxycholic acids contained in Allochol undergo 7α-dehydroxylation in the intestine. Henodeoxycholic acid, in addition, undergoes metabolism in the liver: it conjugates with amino acids, is secreted into bile, from where it is excreted again into the intestine, then partially reabsorbed; the rest is excreted with the feces.

Indications

Used in chronic hepatitis, cholangitis, cholecystitis and habitual constipation associated with bowel atony.

Active ingredient

Composition

1 film-coated tablet contains:

acting substances:

Bile condensed in terms of dry substance or bile dry -80 mg;

dried garlic – 40 mg;

nettle leaves – 5 mg;

activated charcoal – 25 mg.

How to take, the dosage

It is taken orally after meals. Adults are prescribed 1-2 tablets 3-4 times a day. The course of treatment is 3-4 weeks.

In acute conditions 1 tablet 2-3 times a day (for 1-2 months).

Interaction

Drugs containing aluminum hydroxide, cholestyramine, cholestipol reduce absorption (and reduce the effect) – simultaneous administration is not advisable.

Special Instructions

The course of treatment with Allochol can be repeated 2-3 times with a break of 3 months.

Contraindications

Side effects

Diarrhea and allergic reactions are possible when using the drug in some patients. In these cases the drug should be discontinued.

Overdose

Diarrhea, nausea, heartburn, skin itching, increased blood levels of transaminases are possible.