Alfadol-Sa, capsules 30 pcs

Pharmacotherapeutic group
Vitamin – calcium-phosphorus metabolism regulator

ATX code
A11CC
Pharmacological properties
Combined drug regulating calcium and phosphorus metabolism. It replenishes the lack of calcium and vitamin D3 in the body.

The main therapeutic effects of Alfacalcidol are increasing concentration of 1,25-hydroxycalciferol in blood and as a consequence intensification of calcium and phosphate absorption; improvement of mineralization and decrease of bone tissue resorption, normalization of parathyroid hormone in plasma, decrease of bone and muscle pain.

Calcium is involved in the formation of bone tissue, blood clotting, transmission of nerve impulses, skeletal muscle contractions, regulation of the heart.

The rationale for the combination of alfacalcidol and calcium

Alfacalcidol increases absorption of calcium from the gastrointestinal tract and causes therapeutic effect in osteoporosis. Content of elemental calcium in calcium carbonate is 40%, i.e. in 500 mg of calcium carbonate there is 200 mg of elemental calcium, which corresponds to minimal physiological need.

Pharmacokinetics
Absorption is high, TCmax is 8-18 h. In blood it binds with specific alpha-globulins.

It is metabolized in the liver with the formation of the active metabolite calcitriol (1,25-dihydroxycalciferol); a smaller portion is metabolized in bone tissue. Unlike natural vitamin D, it is not metabolized in the kidneys, allowing it to be prescribed for vitamin D deficiency in patients with renal insufficiency (the effect does not depend on hydroxylation in the kidneys). It is excreted by the kidneys and with the bile in approximately equal amounts.

Indications

Composition

How to take, the dosage

Special Instructions

Contraindications

Overdose

Assignments

Pregnancy use