Albumin, 10% 100 ml

Pharmgroup:

Plasma substitute.

Pharmaceutical action:

Pharmaceutical substitute produced by fractionation of human plasma.

Compensates for plasma albumin deficiency, maintains colloidal-osmotic (oncotic) blood pressure, rapidly increases BP and CBC, increases transition and promotes retention of tissue fluid in the bloodstream, increases tissue and organ protein nutrition reserves.

Indications

A decrease in plasma albumin concentration of less than 30 g/L or colloid-oncotic pressure of less than 15 mm Hg, or a decrease in total protein of less than 50 g/L:

hypoalbuminemia of various genesis – shock (hemorrhagic, traumatic, thermal), acute blood loss (decrease of the BOD by more than 25-30%), purulent-septic conditions, liver diseases with impaired albumin synthesis function, kidney disease (nephritis, nephrotic syndrome), burn disease;

operations with the use of artificial circulation;

therapeutic plasmapheresis;

Hemolytic disease in newborns during exchange blood transfusions;

Preoperative hemodilution and harvesting of autologous blood components;

Brain edema (hyperoncotic solutions);

Gastrointestinal diseases with impaired absorption or permeability.

Active ingredient

Composition

In 1 ml of infusion solution contains:

Human albumin 100 mg;

Associates:

sodium caprylic acid,

sodium chloride,

water for injection.

How to take, the dosage

Albumin solution 10% is administered intravenously by drip or stream.

The single dose of the drug depends on the concentration of albumin solution, initial condition and age of the patient. Albumin solutions of 10% are administered in a dose of 200-300 ml.

The rate of administration of 10% albumin solution is not more than 40 drops per minute.

Jet infusion of albumin solutions is acceptable in shocks of various genesis for rapid increase in blood pressure.

In pediatric practice the dosage of albumin solutions is calculated taking into account the concentration in milliliters per kilogram of body weight (not more than 3 ml/kg of child’s body weight).

Interaction

The simultaneous use of albumin with ACE inhibitors increases the risk of arterial hypotension.

Special Instructions

Before using the drug, the doctor registers the label data (drug name, manufacturing company, series number) in the patient’s medical history.

In the elderly, rapid administration of 10% albumin solution should be avoided, as it may lead to cardiovascular overload.

Albumin solutions should be warmed to room temperature before starting the infusion. The drug is not suitable for use in containers with compromised integrity or labeling, with changes in physical properties (color changes, clouding of the solution, the presence of suspended solids, sediment), with expired shelf life, improper storage.

Contraindications

With caution when: renal failure, bronchial asthma, allergic rhinitis, Quincke’s edema.

Side effects

Injection of albumin 10% solution, as a rule, is not accompanied by adverse reactions and complications, sometimes it is possible to develop:

Overdose

In case of overdose or too rapid administration of the drug the phenomenon of hypervolemia may occur (development of pulmonary edema, increased arterial and central venous pressure).

In case of initial signs of anaphylactic reaction or signs of overdose (headache, shortness of breath, suffocation) albumin transfusion should be stopped immediately and without removing the needle from the vein the appropriate drugs (glucocorticosteroids, vasopressor drugs if indicated) should be injected.

Pregnancy use

In pregnancy, the use of human albumin is possible only in cases of extreme necessity.