Akriderm GC, ointment 30 g

A combination drug for external use with anti-inflammatory, anti-allergic, antifungal and antibacterial action.

Gentamicin is a broad spectrum bactericidal antibiotic of aminoglycoside group, highly active against Gram-negative bacteria Proteus spp. (indole-positive and indole-negative strains), Escherichia coli, Klebsiella spp, Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin-resistant). Active against Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Neisseria meningitidis, Treponema pallidum, anaerobic microorganisms (Streptococcus spp. (except Strepnococcus pneumoniae), Providencia rettgeri) are resistant to gentamicin.

Betamethasone has anti-inflammatory, anti-allergic, anti-exudative effects.

Clotrimazole is an antifungal agent from the group of imidazole derivatives. It acts by disrupting the synthesis of ergosterol, which is a part of the cell membrane of fungi. It has a wide spectrum of action. It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeasts and molds (Candida albicans, Turolopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics

In external application of the drug in therapeutic doses, transdermal absorption of the active substances into the blood is very low. When applied to the skin the intensity of absorption of betamethasone depends on the condition of the epidermal barrier (inflammation and skin diseases increase absorption).

The use of occlusive dressings increases transdermal absorption of betamethasone and gentamicin, which may increase the risk of systemic side effects.

Indications

Active ingredient

Composition

Active substances:

betamethasone dipropionate in terms of 100% substance – 0.064 g,

clotrimazole in terms of 100% substance – 1 g,

gentamicin sulfate converted to gentamicin – 0.1 g;

Auxiliary substances:

propyl parahydroxybenzoate (nipazole),

liquid paraffin (petroleum jelly),

isopropyl myristate,

Vaseline.

How to take, the dosage

Over the body.

The ointmentAcrider GC is applied to the affected areas of the skin, rubbing gently, a small amount twice a day. Duration of treatment is determined individually and depends on the nosological form and severity of the disease. With dermatomycosis of feet average duration of treatment is 2-4 weeks. If clinical improvement does not occur soon, it is necessary to specify the diagnosis or change the treatment regimen.

Interaction

Interaction of Acriderma GC with other drugs has not been established.

Special Instructions

It is necessary to avoid contact with the eyes.

In case of resistant bacterial or fungal microflora the drug should be withdrawn, appropriate therapy should be prescribed.

Since children have a larger skin area relative to their body weight in comparison with adults and also the epidermis is underdeveloped, external application of the drug can cause proportionally greater absorption of the active substances and therefore a greater risk of systemic side effects. The drug should be used in children for the shortest time possible and with all precautionary measures taken.

Contraindications

Side effects

Itching, burning, irritation, dry skin, folliculitis, hypertrichosis, steroid acne, hypo-pigmentation, allergic reactions. If occlusive dressings are used – maceration, infection, skin atrophy, stretch marks, sweating. If prolonged treatment or application to a large surface area – development of systemic side effects: weight gain, osteoporosis, increased blood pressure, edema, gastrointestinal mucosa ulceration, aggravation of latent foci of infection, hyperglycemia, agitation, insomnia, dysmenorrhea.

Overdose

Symptoms:phenomena of hypercorticism.

Treatment:gradual withdrawal of the drug. Symptomatic therapy. If necessary, correction of electrolyte abnormalities.

Pregnancy use

During pregnancy (especially in the first trimester) topical use of the ointment in pregnant women is allowed only in cases when the estimated benefit to the mother exceeds the potential risk to the fetus. In such cases, the use of the drug should be of short duration and limited to small areas of the skin.

It is not known whether the components of the drug are excreted with the breast milk. Therefore, when prescribing Acriderm GC ointment during lactation, it is recommended to stop breastfeeding.

Similarities