Afalase, tablets 100 pcs

Pharmacodynamics

It was shown experimentally and clinically that antibodies to prostate-specific antigen (PSA) affinity purified modify the functional activity of endogenous PSA, altered in benign prostatic hyperplasia, which is accompanied by strengthening of the regulatory effect of this antigen on functional and metabolic processes in the prostate tissue, have a pronounced anti-inflammatory and anti-edema effect.

Antibodies to endothelial NO-synthase affinity purified promotes an increase in the rate of blood flow, including in the vessels of the penis and prostate, has a protective effect in relation to the endothelium (helps reduce vascular reactivity, decrease
vascular spasm and improve peripheral microcirculation).

The combined use of the components in the complex preparation “Afalase” is accompanied by a synergetic effect: antibodies to endothelial NO-synthase increase antiproliferative and anti-inflammatory activity of antibodies to PSA due to their endothelioprotective effect and improvement of vascularization. The synergistic effect is probably also due to nonspecific
mechanisms of enhancing intracellular signal transduction by dilutions of antibodies to endothelial NO synthase.

In patients with benign prostatic hyperplasia (BPH) the preparation if used for 12 months facilitates the reduction of the prostate volume, improvement of urodynamic parameters (decrease of residual urine volume, increase of maximum urine velocity), significant decrease of dysuric disorders severity without affecting PSA level. The drug improves quality of life of patients with BPH.

Pharmacokinetics

The sensitivity of modern physico-chemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to estimate the content of active substances of the drug Afalase in biological fluids, organs and tissues, which makes it technically impossible to study pharmacokinetics.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Incompatibilities with other drugs have not yet been registered.

Special Instructions

Synopsis

Contraindications

Side effects

Possible reactions of individual hypersensitivity to the components of the drug.

Overdose

In an accidental overdose, dyspepsia is possible due to the excipients in the drug.

Pregnancy use

Similarities