Aevit, capsules 30 pcs

Pharmacodynamics

Aevit is a combination drug, the effect of which is determined by the properties of its constituent fat-soluble vitamins A and E.

Retinol (vitamin A) is a fat-soluble vitamin that plays an important role as a cofactor in redox processes and participates in the synthesis of mucopolysaccharides, proteins and lipids.

Retinol increases immunity, reduces the effects of a number of infectious diseases and may prevent the development of malignant tumors.

a-Tocopherol acetate (vitamin E) has antioxidant properties, preventing the action of free radicals in biological membranes, is involved in protein synthesis, cell proliferation, tissue respiration. It supports the stability of red blood cells and prevents hemolysis, prevents increased permeability and fragility of capillaries, increases tissue resistance to hypoxia and has a positive effect on lipid metabolism.

Vitamin E helps prevent spontaneous abortion, normalize gonadal function in men, the restoration of skeletal muscles in muscular dystrophy and other muscle lesions. In cardiovascular disease in the treatment of vitamin E normalizes the metabolism in the heart muscle, increases the rate of blood flow in the arterioles, maintaining tension in the venules.

Pharmacokinetics

Retinol palmitate is well absorbed in the upper small intestine, penetrates the lymphatic tract and enters the liver. After administration the maximum concentration in plasma is reached after 4 hours. Retinol is unevenly distributed in the body.

The greatest amount is in the liver and retina, it is found in the kidneys, fat depots, adrenal glands and other glands of internal secretion. Retinol metabolism products are excreted by the kidneys. The half-life is 9.1 hours.

α-Tocopherol acetate is absorbed in the gastrointestinal tract, most of it enters the lymph, is quickly distributed to all tissues and excreted with the bile and as metabolites in the urine.

Indications

Infectious diseases, malnutrition, hypovitaminosis, atherosclerosis, liver cirrhosis

• Hypo- and avitaminosis A and E,
• states of increased demand for vitamins A and E and / or decrease in their intake into the body,
• .increased physical and mental effort, stressful conditions.
• rehabilitation period after prolonged and/or severe diseases, including infectious diseases
• with asthenic conditions of various etiologies
• due to unbalanced and inadequate nutrition.

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Composition

1 capsule contains:

acting substances:

retinol palmitate (vitamin A) 100,000 IU,

alpha-tocopherol acetate (vitamin E) 100 mg

How to take, the dosage

Aevit capsules are taken orally, regardless of meals, 1 capsule daily for 20-40 days at intervals of 3-6 months.

Interaction

When used concomitantly, vitamin A weakens the effect of Ca^{2+ preparations}, increases the risk of hypercalcemia.

Colestyramine, colestipol, mineral oils, neomycin reduce the adsorption of vitamin A and E (their dose may need to be increased).

The oral contraceptives increase the concentration of vitamin A in plasma.

Retinol decreases the anti-inflammatory effects of glucocorticoids.

Isotretinoin increases the risk of vitamin A intoxication.

The simultaneous use of tetracycline and vitamin A in high doses (50,000 units or more) increases the risk of intracranial hypertension.

Vitamin E increases the effect of GCS, NSAIDs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, and cardiac glycosides.

Vitamin E increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood).

The simultaneous use of vitamin E in dose more than 400 units/day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding. High doses of Fe increase oxidative processes in the body, which increases the need for vitamin E.

α-Tocopherol acetate is not recommended to be taken in combination with gold, silver, and alkaline-reacting drugs.

Corticosteroid drugs, antibiotics of the tetracycline group, as well as ethanol and ethanol-containing drugs when combined with Aevit reduce the therapeutic effect.

Special Instructions

With caution is prescribed in cholecystitis, acute and chronic nephritis, conditions with increased vascular permeability, patients with myocardial infarction.

It is not recommended to use together with other multivitamins for a long time, because an overdose of fat-soluble vitamins (A and E) is possible.

Strict adherence to the dosing instructions is necessary because hypervitaminosis A may occur.

The teratogenic effect of high doses of vitamin A persists even after stopping its use, so it is recommended to plan pregnancy only after 6-12 months with the use of the drug.

When using the drug it should be remembered that it has a high vitamin A content (100,000 IU), and that it is a therapeutic drug, not a preventive one.

Contraindications

• High sensitivity to the components of the drug Aevit,
• hypervitaminosis A and E,
• thyrotoxicosis,
• chronic glomerulonephritis,
• chronic heart failure,

children under 14 years of age,

and a history of diabetes,

• hypervitaminosis,

and chronic glomerulonephritis.

• chronic heart failure,
• sarcoidosis in anamnesis,
• children under 14 years old,
• pregnancy.

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