Aevit, capsules, 10 pcs.

Pharmacodynamics

Aevit is a combination drug, the effect of which is determined by the properties of its constituent fat-soluble vitamins A and E.

Retinol (vitamin A) is a fat-soluble vitamin that plays an important role as a cofactor in redox processes and participates in the synthesis of mucopolysaccharides, proteins and lipids. It is necessary for normal reproductive function, embryonic development, proliferation and differentiation of epithelium and osteogenesis. It participates in the formation of visual pigments necessary for normal twilight and color vision. Retinol increases immunity, reduces the effects of a number of infectious diseases, and may prevent the development of malignant tumors.

a-Tocopherol acetate (vitamin E) has antioxidant properties, preventing the action of free radicals in biological membranes, is involved in protein synthesis, cell proliferation, tissue respiration. It supports the stability of red blood cells and prevents hemolysis, prevents increased permeability and fragility of capillaries, increases tissue resistance to hypoxia and has a positive effect on lipid metabolism.

Vitamin E helps prevent spontaneous abortion, normalize gonadal function in men, the restoration of skeletal muscles in muscular dystrophy and other muscle lesions. In cardiovascular disease in the treatment of vitamin E normalizes the metabolism in the heart muscle, increases the rate of blood flow in the arterioles, maintaining tension in the venules.

Pharmacokinetics

Retinol palmitate is well absorbed in the upper small intestine, penetrates the lymphatic tract and enters the liver. After administration the maximum concentration in plasma is reached after 4 hours. Retinol is unevenly distributed in the body. Its greatest amount is in the liver and retina, it is found in the kidneys, fat depots, adrenal glands and other glands of internal secretion. Retinol metabolism products are excreted by the kidneys. The half-life is 9.1 hours.

α-Tocopherol acetate is absorbed in the gastrointestinal tract, most of it enters the lymph, is quickly distributed to all tissues and excreted with the bile and as metabolites in the urine.

Indications

Composition

Composition:

How to take, the dosage

Aevit capsules are taken orally, regardless of meals, 1 capsule daily for 20-40 days at intervals of 3-6 months.

Interaction

When used concomitantly, vitamin A weakens the effect of Ca2+ preparations, increases the risk of hypercalcemia.

Colestyramine, colestipol, mineral oils, neomycin reduce the adsorption of vitamin A and E (their dose may need to be increased).

The oral contraceptives increase the concentration of vitamin A in plasma.

Retinol decreases the anti-inflammatory effects of glucocorticoids.

Isotretinoin increases the risk of vitamin A intoxication.

The simultaneous use of tetracycline and vitamin A in high doses (50,000 units or more) increases the risk of intracranial hypertension.

Vitamin E increases the effect of GCS, NSAIDs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, and cardiac glycosides.

Vitamin E increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood).

The simultaneous use of vitamin E in dose more than 400 units/day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding. High doses of Fe increase oxidative processes in the body, which increases the need for vitamin E.

α-Tocopherol acetate is not recommended to be taken in combination with gold, silver, and alkaline-reacting drugs.

Corticosteroid drugs, antibiotics of the tetracycline group, as well as ethanol and ethanol-containing drugs when combined with Aevit reduce the therapeutic effect.

Special Instructions

With caution is prescribed in cholecystitis, acute and chronic nephritis, conditions with high vascular permeability, patients with myocardial infarction.

It is not recommended to administer together with other multivitamin preparations for a long time because of possible overdose of fat-soluble vitamins (A and E).
It is necessary to follow the instructions of dosage strictly as hypervitaminosis A is possible.
The teratogenic effect of high doses of vitamin A is maintained even after discontinuation of its use, therefore it is recommended to plan pregnancy after 6-12 months after taking the preparation.
It is necessary to take into account the high content of vitamin A (100 ml) in the preparation and its therapeutic and not prophylactic character.

Contraindications

Overdose

Symptoms of acute overdose of retinol (vitamin A) (develop 6 hours after administration): hypervitaminosis A: in adults – drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding gums, dryness and ulceration of the oral mucosa, peeling lips, skin (especially palms), agitation, confusion.

The symptoms of chronic retinol (vitamin A) intoxication: Anorexia, bone pain, cracked and dry skin, lips, dry oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nycturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, nasolabial triangle, hepatotoxic phenomena, increased intraocular pressure, oligomenorrhea, portal hypertension, hemolytic anemia, changes in bone X-rays, seizures; fetotoxic phenomena: in humans – malformations of the urinary system, growth retardation, early closure of epiphyseal growth zones; in animals – malformations of the CNS, spine, thorax, heart, eyes, upper palate, genitourinary system.

The symptoms of tocopherol (vitamin E) overdose: when taken for an extended period in doses of 400-800 IU/day – blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; at intake over 800 IU/day for a long period – increased risk of bleeding in patients with hypovitaminosis K, disorder of thyroid hormone metabolism, sexual dysfunction, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic stroke, ascites.

Treatment: drug withdrawal; symptomatic therapy.

Pregnancy use

With caution is prescribed during pregnancy (especially the first trimester), during lactation.