Adisord, 200 mg/5 ml suspension 90 ml

Pharmacodynamics

Nifuroxazide is an antimicrobial agent derived from nitrofuran. It blocks activity of dehydrogenases and inhibits respiratory chains, tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. It destroys microbial cell membrane and decreases production of toxins by microorganisms.

Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp.; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.

Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp. He disturbs the balance of intestinal microflora.

In acute bacterial diarrhea restores intestinal eubiosis. In case of infection with enterotropic viruses it prevents the development of bacterial superinfection.

Pharmacokinetics

Nifuroxazide is practically not absorbed from the digestive tract after oral administration and its antibacterial effect is exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestine: 20% in unchanged form and the remaining amount of nifuroxazide is chemically changed.

Indications

Active ingredient

Composition

5 ml of the suspension contains:

The active ingredient:

nifuroxazide 200 mg;

Excipients:

Banana flavoring (essence banana) 0.6 mg, carbomer 97IP 9 mg, anhydrous citric acid 0.75 mg, methyl parahydroxybenzoate 5 mg, sodium hydroxide 2 mg, sucrose 1000 mg, ethanol 96% 0.05 ml, purified water to 5 ml.

1 vial contains:

The active ingredient:

Nifuroxazide 3.6 g;

Auxiliary substances:

Banana flavoring (essence banana) 0.0108 g, carbomer 971P 0.162 g, anhydrous citric acid 0.0135 g, methyl parahydroxybenzoate 0.09 g, sodium hydroxide 0.036 g, sucrose 18 g, ethanol 96% 0.9 ml, purified water to 90 ml.

How to take, the dosage

It is administered orally.

A 5 ml dosing spoon with a graduation of 2.5 ml is used for dosing.

The suspension should be shaken well before use.

In children from 1 to 6 months: 100 mg pifuroxazide (2.5 ml of suspension) 2-3 times a day (8-12 hours’ interval between doses).

Children from 6 months to 3 years: 100 mg nifurocoside (2.5 ml of suspension) 3 times daily (8-hour interval between doses).

Children 3 to 6 years: 200 mg nifuroxazide (5 ml of suspension) 3 times daily (8-hour interval between doses).

Children from 6 to 18 years: 200 mg nifuroxazide (5 ml of suspension) 3-4 times a day (interval between doses 6-8 hours).

Adults: 200 mg nifuroxazide (5 ml of suspension) 4 times daily (6-hour interval between doses).

The duration of treatment is 5-7 days, but no more than 7 days. If there is no improvement in the first 3 days of taking it, you should see a doctor. Use only in the way and in the dose stated in the instructions.

If necessary, please talk to your doctor before using this medicine.

Interaction

Special Instructions

In the treatment of diarrhea, rehydration therapy should be given concomitantly with nifuroxazide therapy. Treatment of diarrhea in children under 3 years of age should be carried out under medical supervision.

In case of bacterial diarrhea with signs of systemic involvement (worsening of general condition, increased body temperature, symptoms of intoxication or infection), a physician should be consulted to decide on the use of antibacterial agents of systemic action.

In case of symptoms of hypersensitivity (dyspnea, rash, itching) the drug should be discontinued. Alcohol consumption during therapy with nifuroxazide is prohibited.

The drug may cause allergic reactions (possibly delayed) due to its content of methyl parahydroxybenzoate.

Adisord contains 1000 mg of sucrose in 5 ml. Accordingly, the sucrose content in a single dose of 2.5 ml of the suspension is 0.04165 CFU (bread units), and in a single dose of 5 ml it is 0.0833 CFU.

The daily dose of sucrose is 0.0833 IU when taking 2.5 ml of suspension 2 times a day and 0.125 IU when taking 2.5 ml of suspension 3 times a day.

The daily dose of sucrose is 0.250 IU when given in 5 ml of suspension 3 times daily and 0.333 IU when given in 5 ml of suspension 4 times daily.

The 96% ethanol content of Adisord® suspension is 1%.

The minimum single dose of the drug, corresponding to 100 mg of nifuroxazide (2.5 ml of suspension) contains 0.02 g of ethanol (converted into absolute alcohol), and the maximum daily dose corresponding to 800 mg of nifuroxazide (5 ml of suspension 4 times daily) contains 0.16 g of ethanol (converted into absolute alcohol).

Impact on the ability to drive vehicles and mechanisms

The drug has no effect on the ability to drive vehicles and mechanisms.

Synopsis

Contraindications

With caution

Hepatic diseases, alcoholism, brain injury, brain disease, lactation, pediatric age.

Side effects

Allergic reactions (skin rash, urticaria, Quincke’s edema, anaphylactic shock).

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Pregnancy use

There have been no teratogenic effects in animal studies.

However, as a precautionary measure, taking iifuroxazide during pregnancy is not recommended. During the lactation period it is possible to continue breastfeeding in case of a short course of treatment with the drug. It is necessary to consult a physician.

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