Antiviral drug, synthetic analog of acyclic purine nucleoside, which has a highly selective effect on herpes viruses. A series of sequential reactions of acyclovir transformation into mono-, di- and triphosphate acyclovir takes place inside the virus-infected cells under the action of viral thymidine kinase. Acyclovir triphosphate integrates into the chain of viral DNA and blocks its synthesis by competitive inhibition of viral DNA polymerase.
Indications
Skin itching, Colds
- Treatment of skin and mucous membrane infections caused by Herpes simplex viruses type I and II, both primary and secondary, including genital herpes.
- Prevention of relapsing infections caused by Herpes simplex viruses type I and II in patients with normal immune status
- Prevention of primary and relapsing infections caused by Herpes simplex viruses type I and II in immunodeficient patients.
- In complex therapy of patients with severe immunodeficiency: in HIV-infection (stage of AIDS, early clinical manifestations and advanced clinical picture) and in patients who have undergone bone marrow transplantation.
- Treatment of primary and recurrent infections caused by Varicella zoster virus (chicken pox as well as shingles – Herpes zoster).
Active ingredient
Acyclovir
How to take, the dosage
Orally. The drug is taken during or immediately after a meal with plenty of water.
Interaction
Concomitant use with probenecid increases the average half-life and decreases the clearance of acyclovir.
Concomitant use with nephrotoxic drugs increases the risk of renal dysfunction.
.
Special Instructions
Use strictly as directed by your doctor to avoid complications in adults and children over 3 years of age.
Contraindications
- High sensitivity to acyclovir, ganciclovir or any excipient of the drug.
- The drug is contraindicated during lactation.
- Children under 3 years of age (for this dosage form).
- Galactose intolerance, lactase deficiency, glucose-galactose malabsorption.
With caution:
Pregnancy; the elderly and patients receiving large doses, especially against the background of dehydration; renal dysfunction; neurological disorders or neurological reactions to cytotoxic drugs (including anamnesis).
Side effects
The drug is usually well tolerated.
Overdose
Ingestion of 20 g of acyclovir has been reported. Symptoms: agitation, coma, convulsions, lethargy. Precipitation of acyclovir in the renal tubules is possible if its concentration exceeds renal tubule solubility (2.5 mg/ml).
Parenteral overdose (when given by bolus injection, or when used in high doses, or in patients whose water-electrolyte balance was not properly controlled): increased urea nitrogen, hypercreatininemia, renal dysfunction, lethargy, seizures, coma.
Treatment: maintenance of vital functions, hemodialysis.
Pregnancy use
Acyclovir penetrates the placental barrier and accumulates in breast milk.
The use during pregnancy is possible only if the estimated benefit to the mother exceeds the potential risk to the fetus.
If it is necessary to take acyclovir during lactation, interruption of breastfeeding is required.
Similarities
Zovirax, Vivorax, Acyclovir-Acri, Acyclovir, Herperax, Acyclovir Belupo, Acyclovir Sandoz
Weight | 0.043 kg |
---|---|
Shelf life | 2 years. |
Conditions of storage | Store in a dry, protected from light, out of the reach of children, at a temperature not exceeding 25 ° C. |
Manufacturer | Obolenskoe FP JSC, Russia |
Medication form | pills |
Brand | Obolenskoe FP JSC |
Related products
Buy Acyclovir forte, tablets 400 mg 20 pcs with delivery to USA, UK, Europe and over 120 other countries.