Actovegin, 200 mg 50 pcs.

A drug that activates tissue metabolism, reduces tissue hypoxia, improves trophism and stimulates the regeneration process. It is a hemoderivate, which is obtained by dialysis and ultrafiltration (penetrates compounds with a molecular weight of less than 5000 daltons).

Positively affects the transport and utilization of glucose, stimulates oxygen consumption (which leads to stabilization of plasma cell membranes during ischemia and reduction of lactate formation) thus having an antihypoxic effect.

Actovegin not only increases intracellular glucose content but also improves oxidative metabolism, this improves cellular energy supply as evidenced by increased concentration of direct free energy transporters such as ATP, ADP, phosphocreatine and amino acids such as glutamate, aspartate and GABA.

In disorders of metabolism and blood supply to the brain, such as cerebral insufficiency syndrome (dementia), the transport of glucose through the BBB and its utilization by cells is impaired. PDH activity and acetylcholine concentration also decrease. Administration of Actovegin helps to normalize these figures, improves glucose transport and utilization, with increased oxygen consumption.

Actovegin has been shown to have the same effect in peripheral (arterial, venous) circulatory disorders and the corresponding consequences of such disorders (arterial angiopathy, ulcers of the lower extremities) as well as when used to accelerate wound healing. In case of ulcers of various etiology, trophic disorders (bedsores), burns and radiation injuries Aktovegin improves not only morphological but also biochemical parameters of granulation, for example, concentration of DNA, hemoglobin and hydroxyproline increases.

The effect of Actovegin starts to show no later than 30 min after oral administration and reaches a maximum on average in 3 h (2-6 h).

Indications

Impaired cerebral circulation, Tinnitus, Trophic ulcers, Acquired dementia, Dizziness, Headache, Concussion and other craniocerebral injuries, Stroke aftermath

• peripheral (arterial and venous) vascular disorders and their consequences (angiopathy, trophic ulcers).

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Active ingredient

Deproteinized calf blood hemoderivative

Composition

1 tablet contains:

Active substances:

deproteinized hemoderivate from calf blood – 200 mg.

Additional Ingredients:

magnesium stearate – 2.0 mg,

talc – 3.0 mg.

Shell composition:

Acacia gum – 6.8 mg,

mountain glycol wax – 0.1 mg,

hypromellose phthalate – 29.45 mg,

diethyl phthalate – 11.8 mg,

quinoline yellow varnish aluminum dye – 2.0 mg,

macrogol-6000 – 2.95 mg,

povidone-K 30 – 1.54 mg,

sucrose – 52.3 mg,

talc – 42.2 mg,

titanium dioxide – 0.86 mg.

How to take, the dosage

Prescribe 1-2 tablets. 3 times a day before meals.

The tablet is not chewed, drink a small amount of water.

The duration of treatment is 4-6 weeks.

Interaction

Drug interaction of the drug Aktovegin has not been established.

Special Instructions

If allergic reactions develop, Actovegin should be discontinued. If necessary, standard therapy of allergic reactions (antihistamines and/or GCS) is carried out.

Contraindications

• high sensitivity to the drug.

With cautiousness the drug should be prescribed in cases of heart failure stage II-III, pulmonary edema, oliguria, anuria, hyperhydration, diabetes mellitus, hyperglycemia.

Side effects

Allergic reactions: urticaria, edema, drug fever.

Overdose

Information on overdose of Actovegin is not provided.