Acidin-pepsin, tablets 0,25 g 50 pcs

Pharmacodynamics

Pepsin is one of the main proteolytic enzymes of the digestive tract. It is produced in the cells of the mucous membrane of the stomach in its inactive form – as a proenzyme pepsinogen, which is converted into the active enzyme pepsin in the gastric contents.

It acts at the initial stage of protein digestion in the digestive tract; in the acidic environment of the stomach contents it hydrolyzes proteins to peptides, among the hydrolysis products there are amino acids. At pH 5.0 it causes curdling of milk.

Acidine (betaine hydrochloride) helps increase the acidity of the gastrointestinal juice and creates the optimal pH for pepsin activity. 0.4 g of betaine hydrochloride corresponds to about 16 drops of diluted hydrochloric acid.

Pharmacokinetics

Pepsin exhibits optimal activity at pH 1.4-2.5; if the pH is increased, activity decreases and ceases at pH greater than 6.0.

It breaks down in the duodenum under the action of pancreatic enzymes.

Betaine hydrochloride, when introduced into the stomach, is readily hydrolyzed with the release of free hydrochloric acid.

Indications

Used in hypo- and anacid gastritis, achily, dyspepsia.

Active ingredient

Composition

1 tablet contains:

Acidine (betaine hydrochloride) – 200 mg,

Pepsin – 50 mg.

How to take, the dosage

Dose for adults: 2 tablets 3 – 4 times a day;

for children – from 1/4 to 1 tablet depending on age 3 – 4 times a day.

The tablets are dissolved in 1/4 to 1/2 cup of water before taking.

Take during or after meals.

Interaction

The effect is reduced with simultaneous administration of bases (antacids), heavy metals, tannin, acid-reactive drugs. Pepsin is destroyed by alcohol.

Contraindications

Individual intolerance.

Side effects

Mild nausea and heartburn may occur (rarely).