Acidin-pepsin, tablets 0,25 g 50 pcs

Pharmacodynamics

Pepsin is one of the main proteolytic enzymes of the digestive tract. It is produced in the cells of the mucous membrane of the stomach in its inactive form – as a proenzyme pepsinogen, which is converted into the active enzyme pepsin in the gastric contents.

It acts at the initial stage of protein digestion in the digestive tract; in the acidic environment of the stomach contents it hydrolyzes proteins to peptides, among the hydrolysis products there are amino acids. At pH 5.0 it causes curdling of milk.

Acidine (betaine hydrochloride) helps increase the acidity of the gastrointestinal juice and creates the optimal pH for pepsin activity. 0.4 g of betaine hydrochloride corresponds to about 16 drops of diluted hydrochloric acid.

Pharmacokinetics

Pepsin exhibits optimal activity at pH 1.4-2.5; if the pH is increased, activity decreases and ceases at pH greater than 6.0.

It breaks down in the duodenum under the action of pancreatic enzymes.

Betaine hydrochloride, when introduced into the stomach, is readily hydrolyzed with the release of free hydrochloric acid.

Indications

Used for hypo- and anacid gastritis, achylia, dyspepsia.

Pharmacological effect

Pharmacodynamics

Pepsin is one of the main proteolytic enzymes of the digestive tract. It is produced in the cells of the gastric mucosa in an inactive form – as the proenzyme pepsinogen, which is converted into the active enzyme pepsin in the gastric contents.

Acts at the initial stage of protein digestion in the digestive tract; in the acidic environment of gastric contents, it hydrolyzes proteins to peptides; among the products of hydrolysis there are also amino acids. At pH 5.0 it causes milk to curdle.

Acidin (betaine hydrochloride) helps increase the acidity of gastrointestinal juice, creating an optimal pH for pepsin activity. 0.4 g of betaine hydrochloride corresponds to approximately 16 drops of dilute hydrochloric acid.

Pharmacokinetics

Pepsin exhibits optimal activity at pH 1.4-2.5; if the pH increases, the activity decreases; if the pH is more than 6.0, it stops.

It is destroyed in the duodenum under the action of pancreatic enzymes.

Betaine hydrochloride, when administered into the stomach, is easily hydrolyzed to release free hydrochloric acid.

Active ingredient

Betaine, Pepsin

Composition

Active substances:
betaine hydrochloride (acidine) – 200 mg;
pork pepsin – 0.5 mg;
Excipients:
povidone K-25,
anhydrous colloidal silicon dioxide,
calcium stearate, sorbitol.

Contraindications

Individual intolerance.

Side Effects

Mild nausea and heartburn may occur (rarely).

Interaction

The effect is reduced by simultaneous intake of bases (antacids), heavy metals, tannin, and acid-reacting drugs. Pepsin is destroyed by alcohol.

Storage conditions

Store at a temperature not exceeding +25°C.

Manufacturer

Belmedpreparaty, Belarus