Aciclovir-Acrihin, tablets 400 mg 20 pcs

The antiviral drug is a synthetic analog of thymidine nucleoside.

In infected cells containing viral thymidine kinase is phosphorylated and converted into acyclovir monophosphate. Under the influence of guanylate cyclase acyclovir monophosphate is converted to diphosphate and to triphosphate under the influence of several cellular enzymes. High selectivity and low toxicity for humans is conditioned by absence of necessary enzyme for acyclovir triphosphate formation in intact cells of macroorganism.

Aciclovir triphosphate “embedding” into DNA synthesized by the virus blocks virus multiplication. Specificity and very high selectivity of action are also due to its preferential accumulation in cells affected by the herpes virus. It is highly active against Herpes simplex viruses of types 1 and 2; Varicella zoster viruses; Epstein-Barr viruses (types of viruses are listed in ascending order of MAC value of acyclovir).

It is moderately active against CMV. In herpes it prevents formation of new rash elements, reduces the probability of cutaneous dissemination and visceral complications, accelerates crusts formation, reduces pain in the acute phase of herpes zoster. It has an immunostimulatory effect.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Concomitant use with probenecid increases the average half-life and decreases the clearance of acyclovir.

Concomitant use with nephrotoxic drugs increases the risk of renal dysfunction.

Special Instructions

Acyclovir should be used with caution in patients with impaired renal function, elderly patients due to the increased elimination half-life of acyclovir. When using the drug it is necessary to ensure adequate intake of fluids.

The ointment is not recommended to apply to the mucous membranes of the mouth, eyes and genitals because marked local inflammation may develop. The efficiency of treatment with the use of ointment will be higher the earlier it is started.

Patients with immunodeficiency sometimes develop resistance to acyclovir in repeated courses of treatment. While taking the drug it is necessary to monitor renal function (blood urea and plasma creatinine levels).

Contraindications

With caution:

– pregnancy;

– old age;

– dehydration;

– renal failure;

– neurologic abnormalities or neurologic reactions to cytotoxic drugs (including a history of

– neurological disorders or neurological reactions to cytotoxic drugs (including a history of such reactions).

Side effects

Digestive system disorders: Nausea, vomiting, diarrhea, abdominal pain; rarely, reversible increase in bilirubin and activity of “liver” enzymes.

With the hematopoietic system: very rarely – anemia, leukopenia, thrombocytopenia.

Since the urinary system: rarely – increase in urea and creatinine in the blood; very rarely – acute renal failure.

From the central nervous system: headache, weakness, dizziness, increased fatigue, confusion, hallucinations, drowsiness, paresthesias, seizures, decreased concentration, agitation.

Allergic reactions: zud, rash, Lyell’s syndrome, urticaria, erythema multiforme exudative, including Stevens-Johnson syndrome, angioedema, anaphylaxis.

Other: fever, lymphoadenopathy, peripheral edema, visual disturbances, myalgia, alopecia.

Pregnancy use

Similarities