Aciclovir-Acrihin, tablets 200 mg 20 pcs

The antiviral drug is a synthetic analog of thymidine nucleoside.

In infected cells containing viral thymidine kinase, it is phosphorylated and converted into acyclovir monophosphate. Under the influence of guanylate cyclase acyclovir monophosphate is converted into diphosphate and under the influence of several cellular enzymes into triphosphate. High selectivity and low toxicity for humans is caused by the absence of necessary enzyme for formation of acyclovir triphosphate in intact cells of macroorganism.

Aciclovir triphosphate, “being built” into the DNA synthesized by the virus, blocks virus multiplication. Its specificity and very high selectivity of action are also due to its preferential accumulation in cells affected by the herpes virus.

Highly active against Herpes simplex viruses of types 1 and 2; Varicella zoster viruses; Epstein-Barr viruses (types of viruses are listed in ascending order of MAC value of acyclovir).

It is moderately active against CMV.

In herpes it prevents formation of new rash elements, reduces the probability of cutaneous dissemination and visceral complications, accelerates crust formation, reduces pain in the acute phase of herpes zoster. It has an immunostimulatory effect.

Indications

Active ingredient

Composition

Active ingredient:

Aciclovir 200 mg.

How to take, the dosage

The dosing regimen is set individually depending on the severity of the disease.

In the treatment of infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, acyclovir is indicated in 200 mg 5 times per day for 5 days at 4-hour intervals during the day and at 8-hour intervals at night for adults and children over 2 years. In more severe cases of the disease, it is possible to increase the course of treatment.

In combination therapy with severe immunodeficiency including advanced clinical manifestations of HIV infection (including early clinical manifestations of HIV infection and AIDS stage), after bone marrow implantation it is indicated in dose 400 mg 5 times per day.

To prevent recurrence of infections caused by Herpes simplex virus types 1 and 2, patients with normal immune status and relapsed disease are prescribed 200 mg 4 times daily every 6 hours.

For prophylaxis of infections caused by Herpes simplex virus types 1 and 2, in adults and children over 2 years of age with immunodeficiency, the drug is indicated in 200 mg 4 times daily every 6 hours; the maximum dose is 400 mg 5 times daily.

In the treatment of infections caused by Varicella zoster virus, adults are prescribed 800 mg 5 times per day at 4-hour intervals during the day and at 8-hour intervals at night. The course of treatment is 7-10 days. Children over 2 years of age are prescribed 20 mg/kg of body weight 4 times/day for 5 days; children with body weight over 40 kg are prescribed in the same dosage as adults.

In treatment of herpes zoster, 800 mg 4 times per day every 6 hours for 5 days in adults. Children over 6 years of age – 800 mg 4 times a day; 2-6 years of age – 400 mg 4 times a day; under 2 years of age – 200 mg 4 times a day. A more precise dose can be determined at the rate of 20 mg/kg, but not more than 800 mg 4 times a day. The course of treatment is 5 days.

In patients with significant renal impairment (RI) in the treatment and prevention of infections caused by Herpes simplex virus, the drug is prescribed 200 mg 2 times daily at 12-hour intervals.

In treatment of infections caused by Varicella zoster virus in patients with CKD the preparation is indicated in 800 mg 2 times per day at 12-hour intervals; in CKD from 10 to 25 ml/min – 800 mg 3 times per day at 8-hour intervals.

The drug should be taken during or immediately after a meal with plenty of water.

Interaction

Concomitant use with probenecid increases the average half-life and decreases the clearance of acyclovir.

Concomitant use with nephrotoxic drugs increases the risk of renal dysfunction.

Special Instructions

Caution should be exercised when prescribing Acyclovir to patients with impaired renal function, elderly patients due to the increased half-life of acyclovir. When using the drug it is necessary to ensure adequate intake of fluids.

Contraindications

Hypersensitivity (including to valacyclovir), children under 3 years of age (for solid LF).

With caution. Pregnancy, period of lactation.

Side effects

Digestive system disorders: in single cases – abdominal pain, nausea, vomiting, diarrhea; rarely – transient increase in liver enzymes activity, hyperbilirubinemia.

With the hematopoietic system: frequently – leukopenia, erythropenia.

CNS side: rarely – headache, weakness; in some cases – tremor, dizziness, increased fatigue, somnolence, hallucinations.

Allergic reactions: skin rash; rarely – allergic dermatitis (when using ointment).

Local reactions: When using the ointment, possible – redness, itching, peeling, burning or tingling.

Others: rarely – alopecia, fever, increased levels of urea and creatinine.

Overdose

Ingestion of 20 g of acyclovir has been reported. Symptoms: agitation, coma, convulsions, lethargy. Precipitation of acyclovir in the renal tubules is possible if its concentration exceeds renal tubule solubility (2.5 mg/ml).

Parenteral overdose (when given by bolus injection, or when used in high doses, or in patients whose water-electrolyte balance was not properly controlled): increased urea nitrogen, hypercreatininemia, impaired renal function, lethargy, seizures, coma.

Treatment:maintenance of vital functions, hemodialysis.

Pregnancy use

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