Acetylcysteine 200 mg, 24 pcs.

Mucolytic remedy. Liquefies sputum, increases its volume, facilitates secretion, promotes expectoration.

The action of acetylcysteine is associated with the ability of its sulfhydryl groups to break disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and reduction of mucus viscosity. It retains activity in the presence of purulent sputum.

It has antioxidant effect due to the presence of SH-group, which is able to interact and neutralize electrophilic oxidizing toxins.

Acetylcysteine promotes synthesis of glutathione which is an important antioxidant factor of intracellular protection and provides maintenance of functional activity and morphological integrity of the cell.

Indications

Respiratory diseases and conditions accompanied by formation of viscous and mucopurulent phlegm: Acute and chronic bronchitis, tracheitis due to bacterial and/or viral infection, pneumonia, bronchiectatic disease, bronchial asthma, atelectasis due to blockage of the bronchi by mucous plugs, sinusitis (to facilitate the discharge of secretions), cystic fibrosis (in the combined therapy).

Removal of viscous secretions from the airways in post-traumatic and post-operative states.

Paracetamol overdose.

Active ingredient

Composition

One effervescent tablet contains:

active ingredient:

acetylcysteine – 200 mg;

excipients:

ascorbic acid – 25 mg,

sodium carbonate anhydrous – 93 mg,

sodium bicarbonate – 894 mg,

citric acid anhydrous – 998 mg,

How to take, the dosage

Individual.

Ingestion for adults and children over 6 years of age – 200 mg 2-3 times a day; children aged 2 to 6 years – 200 mg 2 times a day or 100 mg 3 times a day, up to 2 years – 100 mg 2 times a day. I / m adults – 300 mg 1 time / day, children – 150 mg 1 time / day.

Interaction

Concomitant use of acetylcysteine with cough suppressants may increase sputum congestion due to suppression of the cough reflex.

Simultaneous use with antibiotics (including tetracycline, ampicillin, amphotericin B) may interact with the thiol group of acetylcysteine.

Acetylcysteine reduces hepatotoxic effect of paracetamol.

Contraindications

Gastric and duodenal ulcer in the acute phase, hemoptysis, pulmonary hemorrhage, hypersensitivity to acetylcysteine.

Use in pregnancy and lactation

Adequate and strictly controlled clinical safety studies of acetylcysteine in pregnancy and during lactation have not been conducted.

During pregnancy and lactation, acetylcysteine may be used only if the anticipated benefit to the mother exceeds the potential risk to the fetus or infant.

Acetylcysteine is used with caution in patients with liver disease.

Acetylcysteine is used with caution in patients with kidney disease.

Side effects

The digestive system: rarely – heartburn, nausea, vomiting, diarrhea, a feeling of fullness of the stomach.

Allergic reactions: rarely – skin rash, itching, urticaria, bronchospasm.

A slight and quickly disappearing burning sensation may occur if the drug is not injected deeply in the muscle.

Inhalation: may cause reflex cough, local irritation of airways, rarely – stomatitis, rhinitis.

Other: rare – nasal bleeding, tinnitus.

Laboratory: prothrombin time may decrease while taking high doses of acetylcysteine (coagulation system condition should be monitored), the results of salicylate quantitative determination test (colorimetric test) and ketone quantitative determination test (sodium nitroprusside test) may change.

Similarities