Acesol, 200 ml
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Combined drug, has detoxifying, plasma exchange, rehydration, diuretic, antishock, antiaggregant effect. It reduces hypovolemia, prevents blood clotting and metabolic acidosis development, increases diuresis, improves microcirculation. They are excreted mainly by the kidneys, in small amounts through the intestines, sweat, tears, etc.
In the body acetate is activated into acetyl-coenzyme A, then the main amount of active acetate is completely oxidized in the Krebs cycle to carbon dioxide and water. The acetate oxidation process takes place in muscle cells, so the body’s ability to metabolize it depends mainly on muscle mass. Acetyl-CoA metabolism can also follow the minor oxidation pathway with the formation of fatty acids, keto acids and cholesterol.
- intoxication (acute shigellosis, food poisoning, cholera)
Potassium chloride, Sodium acetate, Sodium chloride
|Infusion solution||. 1 l|
|sodium chloride||5 g||potassium chloride||1 g|
|sodium acetate trihydrate||2 g|
How to take, the dosage
The drug is used only in moderate and severe conditions when oral rehydration solutions cannot be administered; it is administered by IV stream (1-3 hours). Prior to administration the solution is heated to 36-38 ° C. The volume of administered solution is selected individually in the amount necessary to restore the water-electrolyte balance (for severe forms of diseases within 1 hour the solution is administered by trickle in an amount corresponding to 7-10% of the patient’s body weight; then the trickle administration is replaced by dropwise administration at a rate of 40-120 drops/min (24-48 hours)), under control of the laboratory indices. The balance of injected and lost fluids is determined every 6 h. The total amount of solution administered should correspond to the volume of fluid excreted with feces, vomit, urine, and sweat.
Treatment is carried out under control of hematocrit and blood electrolyte concentration.
In case of hyperkalemia the drug is replaced with Dysol solution until normalization of electrolyte balance.
Freezing of the drug is not a contraindication to its use.
Non-wetting of the inner surface of the bottle or polymer container is not a contraindication to the drug administration.
Studies to assess the drug effect on the ability to drive vehicles and engage in other potentially dangerous activities that require high concentration and quick psychomotor reactions have not been conducted. In general, in case of dehydration, administration of special solutions orally is indicated, and only if such administration is impossible (uncontrollable vomiting, pronounced degree of dehydration, severity of general condition, etc.) the drug is administered parenterally.
- chronic renal failure;
- .presence of contraindications to the introduction of large amounts of fluid;
- High sensitivity.
With caution, use in patients with impaired renal excretory function.
Swelling, tachycardia, chills, hyperkalemia.
Symptoms: in patients with chronic kidney disease or in any disease accompanied by impaired potassium excretion or if the drug is administered too rapidly by IV, hyperkalemia may develop, which may potentially be fatal. Early clinical manifestations of hyperkalemia (sharpening of P wave, disappearance of U wave, lowering of ST segment and prolongation of QT interval) usually appear at serum potassium concentration of 7 to 8 mEq/l. More severe symptoms (including muscle paralysis and cardiac arrest) develop at a potassium concentration of 9 to 10 mEq/L. It should be borne in mind that hyperkalemia leading to death may develop rapidly and be asymptomatic.
Treatment: discontinue the drug, in case of hyperkalemia the drug is replaced with “Disol” solution until normalization of electrolyte balance. If necessary, hemodialysis and peritoneal dialysis shall be performed.
Grotex Ltd, Russia
solution for infusion
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