Aceclofenac, 100 mg 20 pcs.

Aceclofenac is a non-steroidal anti-inflammatory agent, a derivative of phenylacetic acid. Aceclofenac has analgesic, anti-inflammatory, antipyretic effects, which are associated with inhibition of cyclooxygenase 1 and 2, which regulate prostaglandin production.

Aceclofenac is well absorbed when taken orally. The maximum concentration is reached after 1.25 – 3 hours. Aceclofenac enters the joint fluid, where its content reaches 57% of plasma concentrations, and the time of maximum concentration is reached 2 – 4 hours longer than in plasma.

The volume of distribution of aceclofenac is 25 liters. With plasma proteins (albumin) aceclofenac is 99% bound.

Aceclofenac circulates mainly unchanged, its main metabolite – 4′-hydroxyaclofenac. half-life is 4 hours. Aceclofenac is excreted by the kidneys, more than 60% in the form of hydroxy derivatives.

Indications

The drug is prescribed:

The use of Aceclofenac is not able to completely cure these diseases, but quickly reduces inflammation and pain.

Active ingredient

Composition

Circular biconvex tablets with white or almost white film coating. On cross-section there is a white or almost white core.

The active ingredients:

Aceclofenac – 100 mg

Excipients:

Composition of the core:

Calcium stearate – 3 mg

Talc – 9 mg

Colloidal silica (aerosil) – 1.5 mg

Microcrystalline cellulose – 85 mg

Sodium croscarmellose (primellose) – 10.5 mg

Lactose monohydrate (milk sugar) – 91 mg

Kernel weight – 300 mg

The composition of the shell:

Hypromellose (hydroxypropyl methylcellulose) – 6.4 mg

Macrogol – 4000 (polyethylene oxide-4000) – 2.5 mg

Titanium dioxide (titanium dioxide) – 1.1 mg

Pill mass – 310 mg

How to take, the dosage

The tablets are prescribed orally. Depending on the disease and age of the patient, 100 to 200 mg of the drug per day is prescribed. 100 mg at a time, whole, without separating or chewing, drinking plenty of fluids.

Oternally. The substance in an ointment or cream is applied in a thin layer gently to the area of inflammation 3 times a day. After using the drug, it is recommended to wash hands thoroughly with soap and water and avoid getting it in the eyes.

Interaction

Anticoagulants in combination with pills increase the risk of bleeding. During treatment, it is recommended to periodically monitor blood clotting parameters.

Aceclofenac tablets increase the plasma concentration of digoxin, phenytoin, lithium-based drugs.

The substance, when combined with antihypertensives and diuretics, reduces the effectiveness of the latter.

Combination of the drug with potassium-saving diuretics increases the possibility of hyperkalemia.

The drug should be combined with NSAIDs and glucocorticosteroids with caution; the drug increases the toxicity of methotrexate and cyclosporine.

Aspirin reduces the plasma concentration of Aceclofenac.

Combination of the drug with hypoglycemic drugs requires continuous monitoring of blood glucose levels.

Special Instructions

As a precautionary measure during treatment with the drug, minimum effective and active dosages are recommended. Periodic monitoring of liver and kidney function, peripheral blood count, fecal status (absence of blood), cardiovascular function are also indicated.

Do not drive a car or perform potentially dangerous activities during treatment.

The risk of allergies or skin reactions is higher in the first months of taking the drug. If lesions of the mouth, skin rashes, or other signs of allergy occur, therapy must be discontinued.

The process of platelet suppression during treatment with the drug is reversible, the blood composition normalizes some time after discontinuation of the drug.

Contraindications

The drug is contraindicated:

Caution should be exercised:

Side effects

At the time of treatment with Aceclofenac, it is common to see:

Rarely developed:

It is very rare:

Overdose

No cases of overdose of the drug in humans have been reported.

The symptoms of overdose are: headaches, seizures, vomiting, abdominal pain, nausea, dizziness. As therapy, enterosorbents are used, the stomach is flushed, symptomatic treatment is carried out. The drug has no specific antidote, hemodialysis and forced diuresis have little effect.

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