Aceclagin, 200 mg 30 pcs

Pharmacotherapeutic group: Non-steroidal anti-inflammatory drug (NSAIDs)

ATCode: M01AB16

Pharmacological properties

Pharmacodynamics

Aceclofenac has anti-inflammatory, analgesic, antipyretic effects. Inhibits the synthesis of prostaglandins and thus affects the pathogenesis of inflammation, pain and fever. In rheumatic diseases the anti-inflammatory and analgesic effect of aceclofenac significantly reduces the severity of pain, morning stiffness, joint swelling which improves the functional state of the patient.

Pharmacokinetics

absorption. Acclofenac is rapidly absorbed after oral administration. Maximum concentration (C_max) in blood plasma is reached 1.25-3 hours after oral administration. Food intake slows down absorption, but does not affect its degree.

Distribution Aceclofenac is highly bound to plasma proteins (˃99.7%). Aceclofenac penetrates into the synovial fluid, where its concentration reaches 60% of its concentration in blood plasma. The volume of distribution is 30 liters.

Metabolism It is believed that aceclofenac is metabolized by CYP2C9 isoenzyme to form the metabolite 4-OH-aceclofenac. Diclofenac and 4-OH-diclofenac are among the numerous metabolites of aceclofenac.

Evolution.The average half-life (T_1/2) of modified-release tablets is about 5 hours. Clearance is 5 l/h. Approximately 2/3 of the dose taken is excreted by the kidneys, mainly as conjugated hydroxymetabolites. Only 1% of the dose after oral administration is excreted unchanged.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

With caution

. History of liver, renal and gastrointestinal diseases, bronchial asthma, arterial hypertension, decreased circulating blood volume (including after extensive surgery), coronary heart disease, chronic renal and hepatic and heart failure, creatinine clearance less than 60 ml/min, history of gastrointestinal ulcers, Helicobacter pylori infection, dyslipidemia/hyperlipidemia, diabetes, smoking, advanced age, long-term use of NSAIDs, severe somatic diseases, alcoholism.

Side effects

Overdose

Pregnancy use

Pregnancy

The use of the drug Aceklagin® is contraindicated in pregnancy. There is no information about the use of Aceclofenac in pregnancy. Inhibition of prostaglandin synthesis may adversely affect the course of pregnancy and/or development of the embryo/fetus.

All prostaglandin synthesis inhibitors during the third trimester of pregnancy:

In late pregnancy:

The drug should not be taken while breastfeeding. There are no data on excretion of aceclofenac with the female milk. In preclinical studies when administering radioactive C-accheclofenac no appreciable transfer of radioactivity into milk was observed.

Fertility

Non-steroidal anti-inflammatory drugs (NSAIDs) may affect fertility and are not recommended for use in women who are planning a pregnancy.

Similarities