Zerkalin, 10 mg/ml 30 ml

Pharmacotherapeutic group

Lincosamide antibiotic.

The ATC code: D10AF01

Pharmacological properties

Pharmacodynamics

Clindamycin is an antibiotic of the lincosamide group, active against all strains of Propionibacteriumacnes, the minimum inhibitory concentration (MIC) is 0.4 µg/ml. It inhibits protein synthesis in the microbial cell due to interaction with 50S-subunits of ribosomes. After application to the skin, the amount of free fatty acids on the skin surface decreases from about 14% to 2%.

Pharmacokinetics

Clindamycin rapidly accumulates in comedones, where it shows antibacterial activity. The average concentration of the antibiotic in the contents of comedones after applying the solution significantly exceeds the minimum suppressive concentration for all strains of Propionibacteriumacnes – the causative agent of acne. After application of clindamycin hydrochloride solution to the skin, very low clindamycin concentrations are detected in plasma and urine.

Indications

The drug is used to treat acne (acnevulgaris).

Active ingredient

Composition

1 ml of the drug contains:

The active ingredient:

clindamycin hydrochloride in terms of clindamycin hydrochloride anhydrous – 11.5 mg (corresponding to 10 mg of clindamycin).

Auxiliary substances:

Ethanol (96% ethyl alcohol),

Propylene glycol,

Purified water.

How to take, the dosage

Interaction

The simultaneous use of clindamycin with other acne medications containing exfoliating, emollient and abrasive substances (e.g., benzoyl peroxide, tretinoin, resorcinol, salicylic acid, sulfur) is not recommended because of possible skin irritation.

There is cross-resistance of microorganisms to clindamycin and lincomycin. Antagonism between clindamycin and erythromycin has been noted.

Clindamycin has been found to disrupt neuromuscular transmission when used systemically and therefore may potentiate the effects of other peripheral myorelaxants, so even though blood levels are significantly lower after external administration of Zerkalin® than after oral clindamycin, the drug should be used with caution in patients receiving this group of drugs.

Special Instructions

Avoid contact of the drug with the mucous membranes of the eyes and mouth. After applying the drug you should wash your hands thoroughly. In case of accidental contact with sensitive surfaces (eyes, skin abrasions, mucous membranes) the area should be rinsed copiously with cool water.

The use of clindamycin (as well as other antibiotics) orally or parenterally in some cases is associated with the development of severe diarrhea and pseudomembranous colitis. Cases of diarrhea and colitis are rare when clindamycin is used topically, however, caution should be exercised and if severe or prolonged diarrhea develops, the drug should be discontinued and appropriate diagnostic and treatment measures taken if necessary.

If necessary, please consult a physician before using the drug.

Impact on ability to drive vehicles, machines

The drug Zerkalin® does not affect the ability to drive vehicles or engage in other potentially hazardous activities requiring increased concentration and quick psychomotor reaction.

Contraindications

With caution: Under 12 years of age, period of lactation, in patients with allergies, and in concomitant administration of muscle relaxants.

Side effects

Classification of adverse reactions by organ and organ system with indication of frequency of occurrence: Very common (≥1/10), common (≥1/100, < 1/10), infrequent (≥1/1000, < 1/100), rare (≥1/10000, < 1/1000), very rare (< 1/10000), including individual reports, frequency unknown (frequency cannot be estimated from available data).

Skin and subcutaneous tissue disorders

Very common: dry skin, skin irritation, urticaria

Frequent: seborrhea

Frequent unknown: contact dermatitis.

Gastrointestinal disorders

Infrequent: digestive disorders

Frequent unknown: Pseudomembranous colitis, abdominal pain

Infectious and parasitic diseases

Frequent unknown: folliculitis.

Visual disorders

Prevalence unknown: eye pain.

If any of the side effects listed in the instructions worsen or other side effects not listed in the instructions are noted, you should tell your doctor immediately.

Overdose

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