Vix Aktiv Symptomax Plus powder for oral solution lemon sachets, 10 pcs.

– Paracetamol – has analgesic and antipyretic effects, these effects are due to the inhibition of prostaglandin synthesis in the central nervous system.
– Guaifenesin – has mucolytic action, facilitates removal of sputum from the bronchi and promotes the transition of non-productive cough into productive.
– Phenylephrine – a postsynaptic agonist of alpha – adrenoreceptors with low cardio-selective affinity for beta – receptors. Decongestant, narrows blood vessels, eliminates swelling and hyperemia of the nasal mucosa.

Indications

Symptoms of colds and flu :

– Headache.

– Sore throat.

– Pain in the body and extremities.

– Nasal congestion.

– Cough with difficult discharge of viscous sputum.

– Increased body temperature

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Active ingredient

Composition

Powder for the preparation of a solution for oral administration 1 bag:

the active ingredients:

Paracetamol 500 mg;

Guaifenesin 200 mg;

Phenylephrine hydrochloride 10 mg.

Auxiliary substances:

sucrose 2000 mg;

citric acid 330 mg;

tartaric acid 330 mg;

sodium cyclamate 200 mg;

sodium citrate 500 mg;

aspartame 6 mg;

p> potassium acesulfame 17 mg;

Lemon flavoring 8476 50 mg;

Lemon juice flavoring 120 mg;

menthol flavoring 100 mg;

quinoline yellow dye 1 mg

How to take, the dosage

Internal. Dissolve the contents of one sachet in hot, but not boiling water (250 ml). Allow to cool to an acceptable temperature and drink. Adults and children over 18 years one bag. If necessary, repeat every 4-6 hours, but no more than 4 doses (sachets) a day. The drug is not recommended to use for more than 5 days as a pain reliever and 3 days as an antipyretic without medical advice. If symptoms persist, a doctor should be consulted.

Interaction

Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which causes the possibility of severe intoxication.

Paracetamol increases the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

The rate of absorption of paracetamol increases under the influence of metoclopramide or domperidone and decreases under the influence of colestyramine.

The anticoagulant effect of warfarin and other coumarin derivatives increases with long-term use of paracetamol.

The drug enhances the effects of MAO inhibitors, sedatives, ethanol.

– Guaifenesin

Codeine makes it difficult to drain diluted sputum. It is compatible with bronchodilators, antimicrobial drugs, cardiac glycosides.

Contraindications

– Hypersensitivity to paracetamol or other components of the drug.

– Hepatic impairment and marked impairment of renal function:

– Arterial hypertension;

– CHD;

– Phenylketonuria (since the drug contains aspartame.

– concomitant use of tricyclic antidepressants, MAO inhibitors, beta-adrenoblockers or their use during the last 2 weeks;

– pregnancy;

– lactation (breastfeeding);

– prostatic hyperplasia;

– glaucoma;

– age under 12 years old;

– sugars/isomaltase deficiency;

– fructose intolerance;

– Glucose-galactose malabsorption;

– gastric and 12 duodenal ulcer in the acute stage

Long-term use of the drug is not recommended. It is necessary to avoid simultaneous use of other antipyretic and / or paracetamol-containing drugs. Do not take the drug while taking alcohol.

With caution: bronchial asthma, COPD, glucose-6-phosphate dehydrogenase deficiency, blood diseases, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndrome), hyperoxaluria.

Side effects

Paracetamol

– Allergic reactions

Rarely – skin rash, urticaria, anaphylaxis, bronchospasm, angioedema.

– Central nervous system

Rarely – Dizziness

– Blood system

Rarely – aplastic anemia , methemoglobinemia, increased arterial pressure. Very rarely – pathological changes in the blood, such as thrombocytopenia, agranulocytosis

– The digestive system

Rarely – nausea and vomiting, dry oral mucosa, hepatotoxic effect.

– Urinary system

Rarely – urinary retention, nephrotoxicity (papillary necrosis).

– Other

Rarely – paresis of accommodation, increased intraocular pressure, Midriasis

– Guaifenesin

– Nervous system

Rarely – Headache, dizziness and drowsiness.

– Digestive system

Rarely – gastrointestinal discomfort, nausea, vomiting and diarrhea.